{"id":"W3034987750","doi":"10.1113/jp279802","title":"Drp1 knockdown induces severe muscle atrophy and remodelling, mitochondrial dysfunction, autophagy impairment and denervation","year":2020,"lang":"en","type":"article","venue":"The Journal of Physiology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre; Institut Universitaire de Gériatrie de Montréal; Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Mitochondrial fission; Cell biology; Mitochondrion; Skeletal muscle; Muscle atrophy; mitochondrial fusion; Autophagy; Biology; Mitochondrial biogenesis; Atrophy; Gene knockdown; Mitophagy; Endocrinology; Apoptosis; Biochemistry; Mitochondrial DNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014278,0.0001212998,0.0001906164,0.00002883185,0.0001093779,0.00001092724,0.0001128322,0.0001371833,0.0000456111],"category_scores_gemma":[0.00008006088,0.00008286586,0.00005845734,0.00005785433,0.0001091036,0.00000976835,0.00008052332,0.0001739783,0.000003692248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006434485,"about_ca_system_score_gemma":0.00004983239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009113489,"about_ca_topic_score_gemma":0.000004050775,"domain_scores_codex":[0.999113,0.0002318232,0.0002732691,0.0001706203,0.00007905133,0.0001322648],"domain_scores_gemma":[0.9993954,0.00003321607,0.000240154,0.0001205028,0.0001153644,0.00009532956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007506941,0.00001904107,0.00005323361,0.00001161709,0.00004375459,0.000001328837,0.000297662,0.0005473806,0.9931923,0.00004948247,0.004073622,0.0009598841],"study_design_scores_gemma":[0.01388327,0.02365485,0.06154845,0.00007744872,0.0007402966,0.002176262,0.001783072,0.003358276,0.6701419,0.006727338,0.2146016,0.001307257],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935371,0.0008079203,0.003552154,0.001292802,0.0006496939,0.000101851,0.000003925929,0.000005041283,0.00004950841],"genre_scores_gemma":[0.9945464,0.0008380859,0.0009217479,0.001561475,0.002008393,0.000001963175,0.00001142062,0.00001184185,0.00009863226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3230504,"threshold_uncertainty_score":0.3379172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0140286193830946,"score_gpt":0.2237513821537105,"score_spread":0.2097227627706159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}