{"id":"W3034987750","doi":"10.1113/jp279802","title":"Drp1 knockdown induces severe muscle atrophy and remodelling, mitochondrial dysfunction, autophagy impairment and denervation","year":2020,"lang":"en","type":"article","venue":"The Journal of Physiology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre; Institut Universitaire de Gériatrie de Montréal; Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Mitochondrial fission; Cell biology; Mitochondrion; Skeletal muscle; Muscle atrophy; mitochondrial fusion; Autophagy; Biology; Mitochondrial biogenesis; Atrophy; Gene knockdown; Mitophagy; Endocrinology; Apoptosis; Biochemistry; Mitochondrial DNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002334326,0.0007176918,0.000612343,0.0005479604,0.0003144706,0.0003453113,0.0003666439,0.0007082715,0.002663266],"category_scores_gemma":[0.0001022892,0.0002466022,0.0005979406,0.0002697277,0.0004896384,0.0003473407,0.0003785937,0.001149877,0.0008134387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004421159,"about_ca_system_score_gemma":0.0002310128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006810838,"about_ca_topic_score_gemma":0.001203041,"domain_scores_codex":[0.9995776,0.00002857521,0.00005590707,0.0001711705,0.00009191543,0.00007488645],"domain_scores_gemma":[0.9997489,0.00002660814,0.0001005279,0.00002103713,0.00002520443,0.00007768524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001248016,0.00002840105,0.0001433235,0.00009817354,0.00001118592,0.0001012903,0.000021408,0.0000399752,0.9986308,0.00005236102,0.00007148819,0.0006768169],"study_design_scores_gemma":[0.00003085082,0.0004924224,0.009765253,0.00002851235,0.00005281622,0.0005670431,0.00007604019,0.0005769167,0.9855812,0.00005828686,0.00276054,0.00001004953],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814659,0.005625797,0.00546387,0.0003429773,0.0001564661,0.0001023341,0.003325412,0.000484619,0.003032626],"genre_scores_gemma":[0.9719172,0.00311352,0.005820457,0.0002541593,0.00002748748,0.0002401937,0.004310779,0.0001326168,0.01418362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002663266,"threshold_uncertainty_score":0.008909464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0140286193830946,"score_gpt":0.2237513821537105,"score_spread":0.2097227627706159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}