{"id":"W3035022428","doi":"10.1038/s41392-020-0189-8","title":"BARMR1-mediated sorafenib resistance is derived through stem-like property acquisition by activating integrin-FAK signaling pathways","year":2020,"lang":"en","type":"letter","venue":"Signal Transduction and Targeted Therapy","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Hubei University; Hubei University of Medicine; National Natural Science Foundation of China","keywords":"Integrin; Signal transduction; Cancer research; Cell biology; Property (philosophy); Chemistry; Medicine; Biology; Computational biology; Receptor; Biochemistry; Philosophy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002412959,0.0007929353,0.0009873075,0.0002331628,0.0004080681,0.0001490493,0.0002503257,0.0009163277,0.00345391],"category_scores_gemma":[0.00002242188,0.0005876901,0.0003621786,0.0006836607,0.0002893766,0.0002860257,0.00002919722,0.003351602,0.00006464978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002044192,"about_ca_system_score_gemma":0.0003141964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005135557,"about_ca_topic_score_gemma":0.000001530187,"domain_scores_codex":[0.9952568,0.0005487612,0.0008021302,0.001330924,0.0012919,0.0007694884],"domain_scores_gemma":[0.9984069,0.0001836384,0.0003081043,0.0004032539,0.0004189364,0.000279127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001653646,0.0001020856,0.00001110878,0.0005016618,0.0003644299,0.00026038,0.001983579,0.00000145789,0.7576146,0.00000146708,0.2339649,0.003540731],"study_design_scores_gemma":[0.00296285,0.0005835757,0.00001347052,0.0004200643,0.00006704646,0.00003400706,0.0005054379,0.0001434218,0.468334,0.0001342848,0.5262238,0.0005780866],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.08152654,0.01730778,0.01406458,0.8780118,0.0008379894,0.005219824,0.0008820511,0.001064625,0.001084825],"genre_scores_gemma":[0.2017248,0.01030242,0.002891656,0.7652599,0.00407498,0.0004378024,0.0063286,0.0006323059,0.008347523],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.2922589,"threshold_uncertainty_score":0.9996575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04510868499739957,"score_gpt":0.2628148858388217,"score_spread":0.2177062008414221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}