{"id":"W3035054253","doi":"10.3390/bioengineering7020057","title":"Pseudopterosin and O-Methyltylophorinidine Suppress Cell Growth in a 3D Spheroid Co-Culture Model of Pancreatic Ductal Adenocarcinoma","year":2020,"lang":"en","type":"article","venue":"Bioengineering","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Prince Edward Island","funders":"Koç Üniversitesi; University of Bath","keywords":"Spheroid; IC50; Gemcitabine; In vitro; Cancer research; Cell culture; Adenocarcinoma; In vivo; Chemistry; Cytotoxicity; Medicine; Internal medicine; Biology; Chemotherapy; Cancer; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000190989,0.0003736357,0.0004743964,0.0002538403,0.0001735175,0.0003031664,0.0002008369,0.0003368394,0.0008087619],"category_scores_gemma":[0.00008547625,0.0001944225,0.0004245603,0.0002580787,0.0001981581,0.0002008365,0.0001740078,0.0008573503,0.0003459916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003178989,"about_ca_system_score_gemma":0.0003231893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00191475,"about_ca_topic_score_gemma":0.004258744,"domain_scores_codex":[0.9997805,0.00003439948,0.00003086763,0.00004184108,0.00007585586,0.00003665094],"domain_scores_gemma":[0.999843,0.00004169992,0.0000332542,0.0000269497,0.00001622641,0.00003889849],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008891719,0.00005478474,0.000116516,0.00002764819,0.000006035768,0.0000501433,0.00003276351,0.0001424601,0.9987854,0.0000538149,0.00007760793,0.0005637531],"study_design_scores_gemma":[0.00001232615,0.0004085038,0.002701468,0.000003502376,0.00001138487,0.0001332918,0.00003361205,0.001886043,0.9935454,0.0000143877,0.00124672,0.000003388645],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922898,0.001268587,0.00318634,0.0001369977,0.00007296171,0.00004105721,0.0007510753,0.0001149735,0.00213811],"genre_scores_gemma":[0.9882012,0.001264001,0.005479409,0.00008063493,0.0000165056,0.0001129153,0.001026288,0.0000290407,0.003790104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00191475,"threshold_uncertainty_score":0.003807187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02981603987475535,"score_gpt":0.2715090689637686,"score_spread":0.2416930290890133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}