{"id":"W3035054253","doi":"10.3390/bioengineering7020057","title":"Pseudopterosin and O-Methyltylophorinidine Suppress Cell Growth in a 3D Spheroid Co-Culture Model of Pancreatic Ductal Adenocarcinoma","year":2020,"lang":"en","type":"article","venue":"Bioengineering","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Prince Edward Island","funders":"Koç Üniversitesi; University of Bath","keywords":"Spheroid; IC50; Gemcitabine; In vitro; Cancer research; Cell culture; Adenocarcinoma; In vivo; Chemistry; Cytotoxicity; Medicine; Internal medicine; Biology; Chemotherapy; Cancer; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001176794,0.0001770982,0.0005717485,0.00008629543,0.00002081903,0.000008516561,0.00009151475,0.0001290849,0.00003370463],"category_scores_gemma":[0.0001139082,0.0001548784,0.00004797611,0.0002108429,0.00008208473,0.00006124134,0.00006011849,0.0002687854,0.000006038836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004356132,"about_ca_system_score_gemma":0.00006661969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004076433,"about_ca_topic_score_gemma":0.000001087231,"domain_scores_codex":[0.9989187,0.00002343312,0.0002988743,0.0002643111,0.0002022332,0.0002925053],"domain_scores_gemma":[0.9994835,0.00005543139,0.00004274463,0.0001350187,0.00005187709,0.0002314899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0003060607,0.0001113504,0.5316336,0.001286811,0.00007313036,0.0001270999,0.002582847,0.0004965303,0.4630613,0.00006001596,0.0002100788,0.00005119501],"study_design_scores_gemma":[0.006549746,0.001603565,0.2354628,0.000339245,0.0003337071,0.0001228567,0.0007616648,0.6179867,0.1363142,0.0000323038,0.00004879128,0.0004443662],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949186,0.001978406,0.001349306,0.0003105584,0.00002000943,0.000330225,0.00002116283,0.0000384501,0.001033262],"genre_scores_gemma":[0.9849823,0.0005288631,0.01414343,0.00006837,0.00008080323,0.0000230866,0.00001365683,0.00002590906,0.0001336396],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6174902,"threshold_uncertainty_score":0.6315757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02981603987475535,"score_gpt":0.2715090689637686,"score_spread":0.2416930290890133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}