{"id":"W3035100062","doi":"10.1016/j.stemcr.2020.05.007","title":"Modeling and Rescue of RP2 Retinitis Pigmentosa Using iPSC-Derived Retinal Organoids","year":2020,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":187,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Moorfields Eye Charity; Moorfields Eye Hospital NHS Foundation Trust; National Centre for the Replacement Refinement and Reduction of Animals in Research; National Centre for the Replacement, Refinement and Reduction of Animals in Research; University of Utah; National Institute for Health and Care Research; UCL Institute of Ophthalmology, University College London; Morehouse School of Medicine; Medical Research Charities Group; Science Foundation Ireland; Health Research Board; University of British Columbia; Wellcome Trust; Fight for Sight","keywords":"Retinitis pigmentosa; Biology; Induced pluripotent stem cell; Organoid; Retinal degeneration; Outer nuclear layer; Retinal; Photoreceptor cell; Cell biology; Gene therapy of the human retina; Retinal regeneration; Rhodopsin; Retina; Genetics; Regeneration (biology); Gene; Neuroscience; Embryonic stem cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001543966,0.000142651,0.0001778876,0.00002305399,0.00006100219,0.00001788363,0.00005955811,0.0001036631,0.00001893381],"category_scores_gemma":[0.00003255664,0.0001439563,0.00005436121,0.00007754095,0.00005020788,0.000004570958,0.0001312061,0.00006340525,7.943248e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006115803,"about_ca_system_score_gemma":0.000103017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003977997,"about_ca_topic_score_gemma":0.0000048018,"domain_scores_codex":[0.9988422,0.00003692359,0.0003962019,0.000381376,0.0001631079,0.0001801696],"domain_scores_gemma":[0.9995005,0.000003301992,0.0001157778,0.0001868335,0.00008362101,0.0001100027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008378007,0.00001493156,0.005447092,0.0001118572,0.00001884017,0.00008830056,0.0003161764,0.0007207713,0.992458,0.000003117398,0.0001006437,0.0006365122],"study_design_scores_gemma":[0.0004919049,0.0002746915,0.0004139722,0.00006638092,0.00004693848,0.0001519223,0.001236905,0.007562309,0.9882401,0.00003003078,0.00110784,0.0003770649],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993247,0.0008322513,0.001593095,0.00008470994,0.00006856651,0.0001454006,0.000002133892,0.00001155116,0.004015246],"genre_scores_gemma":[0.9980736,0.0002219492,0.001275599,0.00009982503,0.00005993832,0.000002893078,0.00003703001,0.0000223823,0.0002067523],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006841538,"threshold_uncertainty_score":0.5870367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01775077007871634,"score_gpt":0.2238152192525179,"score_spread":0.2060644491738016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}