{"id":"W3035100062","doi":"10.1016/j.stemcr.2020.05.007","title":"Modeling and Rescue of RP2 Retinitis Pigmentosa Using iPSC-Derived Retinal Organoids","year":2020,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":187,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Moorfields Eye Charity; Moorfields Eye Hospital NHS Foundation Trust; National Centre for the Replacement Refinement and Reduction of Animals in Research; National Centre for the Replacement, Refinement and Reduction of Animals in Research; University of Utah; National Institute for Health and Care Research; UCL Institute of Ophthalmology, University College London; Morehouse School of Medicine; Medical Research Charities Group; Science Foundation Ireland; Health Research Board; University of British Columbia; Wellcome Trust; Fight for Sight","keywords":"Retinitis pigmentosa; Biology; Induced pluripotent stem cell; Organoid; Retinal degeneration; Outer nuclear layer; Retinal; Photoreceptor cell; Cell biology; Gene therapy of the human retina; Retinal regeneration; Rhodopsin; Retina; Genetics; Regeneration (biology); Gene; Neuroscience; Embryonic stem cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000404004,0.0004726947,0.0003236039,0.0004266723,0.0003391779,0.0005750706,0.0005433534,0.0006741173,0.0009765173],"category_scores_gemma":[0.0001684514,0.0002898064,0.0005970704,0.000179762,0.0003663937,0.000223554,0.0005553751,0.001183217,0.0006756384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003891668,"about_ca_system_score_gemma":0.0003637733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001386465,"about_ca_topic_score_gemma":0.001197807,"domain_scores_codex":[0.9997409,0.00002799854,0.00003886682,0.00004955262,0.0001100847,0.00003255178],"domain_scores_gemma":[0.9997781,0.00004142105,0.0000570777,0.00005102218,0.00003028222,0.0000420605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003716727,0.00002262703,0.0002537683,0.00006973118,0.000009068034,0.000367792,0.00009224315,0.001643149,0.9947856,0.0008309584,0.0001535322,0.001734549],"study_design_scores_gemma":[0.00001723409,0.0001217857,0.00101802,0.00002410654,0.000025968,0.0007183962,0.00007337586,0.005585836,0.9824452,0.0001737493,0.009782911,0.00001344021],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8525187,0.003129682,0.1232159,0.000435032,0.0003477003,0.0005467419,0.004794736,0.001247501,0.01376399],"genre_scores_gemma":[0.944761,0.002062775,0.04288235,0.0001243228,0.00001981078,0.0004197005,0.001996181,0.0002101179,0.007523621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001386465,"threshold_uncertainty_score":0.003266752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01775077007871634,"score_gpt":0.2238152192525179,"score_spread":0.2060644491738016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}