{"id":"W3035130407","doi":"10.7554/elife.52237","title":"Hepatitis C virus exploits cyclophilin A to evade PKR","year":2020,"lang":"en","type":"article","venue":"eLife","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Faculty of Health Sciences, Queen's University; Deutsche Forschungsgemeinschaft; Queen's University; European Commission; Engineering and Physical Sciences Research Council; Canadian Institutes of Health Research; National Institute for Health and Care Research; University College London; Wellcome Trust; Medical Research Council; Wellcome","keywords":"Cypa; Cyclophilin A; Protein kinase R; Hepatitis C virus; Interferon; Innate immune system; Effector; Antiviral protein; Viral replication; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006175703,0.0001253084,0.0001067374,0.00001373727,0.00004212341,0.00001800595,0.000227404,0.00007805775,0.00009154272],"category_scores_gemma":[0.0004816078,0.0001341589,0.00007521865,0.0001038597,0.00002202739,0.000001806089,0.0001563421,0.00006048832,0.0004239097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008954306,"about_ca_system_score_gemma":0.00006711257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003946468,"about_ca_topic_score_gemma":0.00002839706,"domain_scores_codex":[0.999079,0.00003681636,0.0001497506,0.0003508096,0.0001842523,0.0001993779],"domain_scores_gemma":[0.99929,0.000007509618,0.00003108715,0.0002698379,0.00005808247,0.0003434164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008881208,0.00003534488,0.006894029,0.00001145206,0.00002636558,0.00002260329,0.0001793724,0.0001947615,0.9502981,0.00002113039,0.04123871,0.0009893083],"study_design_scores_gemma":[0.0002691782,0.0002141557,0.002393658,0.000009400464,0.00001080313,0.000002188421,0.00001609628,0.00004788617,0.8872524,0.00001330418,0.1095778,0.0001931201],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957119,0.0005307828,0.00130555,0.001400124,0.0001512314,0.0001621792,0.00008286141,0.0000469118,0.0006085062],"genre_scores_gemma":[0.9847782,0.0001196248,0.001039714,0.0129646,0.0008185338,0.00004433158,0.0000678126,0.00003092674,0.0001362643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06833904,"threshold_uncertainty_score":0.547084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02260253021849354,"score_gpt":0.2571391309500581,"score_spread":0.2345366007315645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}