{"id":"W3035130407","doi":"10.7554/elife.52237","title":"Hepatitis C virus exploits cyclophilin A to evade PKR","year":2020,"lang":"en","type":"article","venue":"eLife","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Faculty of Health Sciences, Queen's University; Deutsche Forschungsgemeinschaft; Queen's University; European Commission; Engineering and Physical Sciences Research Council; Canadian Institutes of Health Research; National Institute for Health and Care Research; University College London; Wellcome Trust; Medical Research Council; Wellcome","keywords":"Cypa; Cyclophilin A; Protein kinase R; Hepatitis C virus; Interferon; Innate immune system; Effector; Antiviral protein; Viral replication; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009259005,0.0002015799,0.00008892341,0.0001284549,0.0001546841,0.0002485716,0.00009625364,0.0001727861,0.0007346316],"category_scores_gemma":[0.00004891993,0.00006462153,0.0001248399,0.00006620715,0.0001785001,0.0001271469,0.0002007921,0.0002813133,0.0002460463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002572008,"about_ca_system_score_gemma":0.0001739003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003587451,"about_ca_topic_score_gemma":0.0006784639,"domain_scores_codex":[0.9999409,0.00001290175,0.000003487983,0.00001087852,0.00001469565,0.0000172082],"domain_scores_gemma":[0.9999756,0.000003018541,0.000007547544,0.000003531095,0.00000231785,0.000008167989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005193345,0.00001155078,0.0003186556,0.00001610493,0.000004444033,0.00005311727,0.000003782173,0.00008245013,0.9968252,0.0004227581,0.00009423881,0.002115864],"study_design_scores_gemma":[0.00001965814,0.0002800718,0.008028015,0.000008296804,0.00001256251,0.0006730732,0.00003008564,0.002673282,0.9807894,0.0003399051,0.007138953,0.000006792118],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843156,0.003279583,0.005025876,0.000520225,0.00006421263,0.00001980811,0.0001733161,0.0001365206,0.006464934],"genre_scores_gemma":[0.9964641,0.0007919068,0.001029815,0.00007348403,0.00001310716,0.00000613214,0.00008595447,0.000005511049,0.001530058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007346316,"threshold_uncertainty_score":0.002457559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02260253021849354,"score_gpt":0.2571391309500581,"score_spread":0.2345366007315645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}