{"id":"W3035191018","doi":"10.1158/2159-8290.cd-19-1493","title":"Epigenetic Switch–Induced Viral Mimicry Evasion in Chemotherapy-Resistant Breast Cancer","year":2020,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":148,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Structural Genomics Consortium; McGill University; McGill University Health Centre; University Health Network; University of Toronto; Université de Montréal; Princess Margaret Cancer Centre; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research; AbbVie; Terry Fox Research Institute; Canadian Cancer Society; Innovative Medicines Initiative; Stand Up To Cancer Canada","keywords":"Epigenetics; Biology; Epigenetic therapy; Triple-negative breast cancer; Cancer; Cancer research; Breast cancer; Genetics; DNA methylation; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008142121,0.0002119472,0.0002047867,0.00003699864,0.00004873478,0.00004851583,0.0001902324,0.0001553354,0.0000751171],"category_scores_gemma":[0.00001484746,0.0002028601,0.0001034366,0.0001574225,0.00003864348,0.0000133574,0.00007507241,0.0001178431,0.0000053059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007624939,"about_ca_system_score_gemma":0.0002508083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004434223,"about_ca_topic_score_gemma":0.0004926347,"domain_scores_codex":[0.9987056,0.00005241006,0.000271028,0.0005097978,0.0001606517,0.0003005401],"domain_scores_gemma":[0.9994753,0.000007364041,0.0001013006,0.000249454,0.00004914834,0.0001174508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003932632,0.00004181639,0.02229024,0.0000384367,0.00003275996,0.000002839322,0.0001212829,0.0007331708,0.9659815,0.00001020459,0.0002206016,0.01013385],"study_design_scores_gemma":[0.001153406,0.0001736161,0.1371623,0.0000653198,0.00002289098,6.104223e-7,0.00007285429,0.0002232545,0.8564142,0.00008608401,0.004272167,0.0003532476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880067,0.008550173,0.0004706134,0.002074536,0.0002533464,0.0002414922,0.0001337453,0.00001098611,0.0002584642],"genre_scores_gemma":[0.9925401,0.00488858,0.00005956456,0.001551623,0.0006509916,0.00007995773,0.00005348679,0.00004453374,0.0001311847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1148721,"threshold_uncertainty_score":0.8272393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.017522589294325,"score_gpt":0.2749192789931967,"score_spread":0.2573966896988717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}