{"id":"W3035203386","doi":"10.1002/advs.202000532","title":"Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation","year":2020,"lang":"en","type":"article","venue":"Advanced Science","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"National Key Research and Development Program of China; Shanghai Minhang Science and Technology Commission; National Natural Science Foundation of China","keywords":"RNA Helicase A; RNA; Cell biology; Biology; Helicase; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009415846,0.0003834954,0.0002346306,0.00009740254,0.000340391,0.0003137262,0.0003092286,0.0004745943,0.00124941],"category_scores_gemma":[0.0001546343,0.0001677207,0.0001932414,0.0001092588,0.0002639888,0.0002829865,0.0002567811,0.0003179147,0.0005291477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004217727,"about_ca_system_score_gemma":0.0002489556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006535526,"about_ca_topic_score_gemma":0.00049553,"domain_scores_codex":[0.999921,0.00001387937,0.000006387014,0.00002168374,0.00002068728,0.00001628069],"domain_scores_gemma":[0.9999467,0.000006671006,0.00001491335,0.000004624415,0.00000687536,0.00002019093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004948091,0.0001067217,0.00165444,0.0002216486,0.00002560997,0.001256997,0.00009878398,0.003126191,0.9805069,0.00471286,0.0006612897,0.007133767],"study_design_scores_gemma":[0.0001711243,0.0007208177,0.01894136,0.00005116593,0.00007661412,0.002800674,0.0001923083,0.03591505,0.904588,0.005800542,0.03068634,0.00005603851],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9769992,0.008494773,0.007931679,0.000468582,0.0001030644,0.00005017385,0.0003124021,0.0001738519,0.005466309],"genre_scores_gemma":[0.9941406,0.001510169,0.002060196,0.0001047465,0.00002313173,0.00001902989,0.000586922,0.0000137154,0.001541447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00124941,"threshold_uncertainty_score":0.004179657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0181950866894744,"score_gpt":0.2788700990674521,"score_spread":0.2606750123779777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}