{"id":"W3035220441","doi":"10.1096/fj.202000239rr","title":"Nuclear respiratory factor 1 (NRF‐1) upregulates the expression and function of reduced folate carrier (RFC) at the blood‐brain barrier","year":2020,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Government of Canada","keywords":"Choroid plexus; Chromatin immunoprecipitation; Downregulation and upregulation; Folate receptor; Transcription factor; Calcitriol receptor; Blood–brain barrier; Cell biology; Biology; Chemistry; Molecular biology; Receptor; Cancer research; Gene expression; Biochemistry; Promoter; Central nervous system; Endocrinology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007496732,0.0001530469,0.0002162384,0.00004478415,0.0006950314,0.00006713058,0.0002483925,0.00009273786,0.001172855],"category_scores_gemma":[0.0003348361,0.00006179787,0.0001441363,0.0001775472,0.0003279642,0.0001123236,0.0001968477,0.0007440592,0.00002184148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003048939,"about_ca_system_score_gemma":0.0001046484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009456813,"about_ca_topic_score_gemma":0.000002316858,"domain_scores_codex":[0.9983042,0.0003870688,0.0003081756,0.0001775815,0.0005484817,0.0002744783],"domain_scores_gemma":[0.9988492,0.0002570306,0.0001595764,0.0003607987,0.0001223317,0.0002510754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009574831,0.00001886443,0.001663309,0.00002307121,0.0001612066,0.00002154245,0.003550762,0.000006467474,0.9812457,0.00001767557,0.009481092,0.002852822],"study_design_scores_gemma":[0.002616374,0.001741058,0.03152165,0.0001697481,0.0003287219,0.000315114,0.00250344,0.0003392441,0.925363,0.0001153885,0.03482588,0.0001603729],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987246,0.001691676,0.000005933832,0.01033073,0.0001127965,0.0002873809,0.00001999458,0.00001666105,0.0002888227],"genre_scores_gemma":[0.9956993,0.000151267,0.00000907748,0.00209694,0.0004655201,0.000003282519,0.000001934572,0.00003108632,0.001541551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05588269,"threshold_uncertainty_score":0.9997402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03422130604358473,"score_gpt":0.2738677760400673,"score_spread":0.2396464699964826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}