{"id":"W3035220500","doi":"10.1093/braincomms/fcaa065","title":"Origins of atrophy in Parkinson linked to early onset and local transcription patterns","year":2020,"lang":"en","type":"article","venue":"Brain Communications","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of Neurological Disorders and Stroke; National Institutes of Health; Radiological Society of North America","keywords":"Atrophy; Parkinson's disease; Disease; Posterior cortical atrophy; Biology; Neuroscience; Locus (genetics); Genetics; Gene; Medicine; Pathology; Dementia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006694487,0.00009222621,0.0001918727,0.00008451613,0.00004860772,0.000008820497,0.0001590064,0.00004763748,0.0000215507],"category_scores_gemma":[0.00004020732,0.00009090094,0.00005029147,0.0002233861,0.00005105828,0.00004529574,0.00006459402,0.0001222578,0.0000166697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009194519,"about_ca_system_score_gemma":0.00004870143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007979569,"about_ca_topic_score_gemma":0.0003366076,"domain_scores_codex":[0.9993261,0.00008734101,0.0002020986,0.000161646,0.0001086682,0.000114186],"domain_scores_gemma":[0.9991266,0.00007622323,0.00003928793,0.0005252019,0.00003431703,0.0001984008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00106266,0.002332072,0.8541009,0.0003095174,0.0003092059,0.00006975895,0.01364711,0.00003954876,0.02658324,0.01127757,0.0006507018,0.08961767],"study_design_scores_gemma":[0.001928452,0.0004749692,0.9245108,0.0001204367,0.00007101906,0.00000493072,0.000299803,0.00135787,0.000404238,0.0001627187,0.07056709,0.00009766754],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9750946,0.0003162713,0.003869362,0.02000699,0.00001382789,0.0004092988,0.0001318342,0.00003035554,0.0001274112],"genre_scores_gemma":[0.9947921,0.000217789,0.003003759,0.001792119,0.00001273264,0.00006182347,0.00009371179,0.00001361429,0.00001232957],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08952,"threshold_uncertainty_score":0.3706833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04544680201419695,"score_gpt":0.2994713858657729,"score_spread":0.254024583851576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}