{"id":"W3035233083","doi":"10.1007/s13555-020-00411-w","title":"Brodalumab to the Rescue: Efficacy and Safety of Brodalumab in Patients with Psoriasis and Prior Exposure or Inadequate Response to Biologics","year":2020,"lang":"en","type":"review","venue":"Dermatology and Therapy","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Bausch Health; Ortho Dermatologics","keywords":"Medicine; Secukinumab; Ixekizumab; Psoriasis; Ustekinumab; Immunology; Dermatology; Disease; Internal medicine; Adalimumab; Psoriatic arthritis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003437227,0.0005203465,0.001779608,0.0002582305,0.0002196233,0.00001615858,0.0002662193,0.0006713796,0.00002514816],"category_scores_gemma":[0.0001735824,0.0002735746,0.00008174579,0.0004261103,0.0002760578,0.00004047569,0.0001569164,0.0003322068,0.00002175995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002506464,"about_ca_system_score_gemma":0.0001498774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002320236,"about_ca_topic_score_gemma":0.00006499316,"domain_scores_codex":[0.9965906,0.001703817,0.0006262647,0.0006538294,0.00004611638,0.0003793988],"domain_scores_gemma":[0.9981893,0.001060556,0.0002227772,0.0004037912,0.00005264794,0.00007093167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.02311253,0.0001417236,0.002870873,0.0003277989,0.0006686032,0.00003472196,0.001278035,1.695464e-7,0.0000108843,0.00004579492,0.00009613419,0.9714127],"study_design_scores_gemma":[0.01008689,0.002590877,0.06474398,0.001032763,0.000391212,0.0003187367,0.00008492893,7.950657e-8,0.00007405702,0.00001150885,0.9202068,0.0004581815],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.3649255,0.6326567,0.00000298329,0.0005924971,0.0001367644,0.001498464,0.00016181,0.00001968601,0.000005589814],"genre_scores_gemma":[0.06156364,0.9376111,0.00008898412,0.0003191089,0.00001702664,0.0001618034,0.0001211821,0.00003605202,0.00008110352],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9709545,"threshold_uncertainty_score":0.9999716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02435962657866465,"score_gpt":0.2715858123556578,"score_spread":0.2472261857769931,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}