{"id":"W3035321276","doi":"10.1101/2020.06.15.149021","title":"Recombinant T cell receptors specific for HLA-A*02:01-restricted neoepitopes containing KRAS codon 12 hotspot mutations","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Burnaby Hospital; Simon Fraser University; BC Cancer Agency; Centre Hospitalier de l’Université de Montréal; University of British Columbia; Pancreas Centre (Canada); Canada's Michael Smith Genome Sciences Centre","funders":"BC Cancer Foundation; National Institutes of Health; University of Melbourne; Cancer Research Institute; American Association for Cancer Research","keywords":"T-cell receptor; KRAS; CD8; Biology; T cell; Molecular biology; CD3; Cancer research; Cytotoxic T cell; Antigen; Genetics; Gene; Mutation; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001064872,0.0003677129,0.0002168476,0.0001589807,0.00008169006,0.0002737217,0.0001915986,0.0002666405,0.00204827],"category_scores_gemma":[0.000158868,0.0001750026,0.0002118177,0.0001798079,0.00009630176,0.0001119343,0.0001733802,0.0007837356,0.001013612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001390342,"about_ca_system_score_gemma":0.0000925589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001929683,"about_ca_topic_score_gemma":0.0001563455,"domain_scores_codex":[0.9997743,0.00003914932,0.00002564103,0.00004536462,0.00004818233,0.00006745078],"domain_scores_gemma":[0.9998738,0.00003197379,0.00002703442,0.00002788899,0.00001691814,0.00002236106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004890019,0.00002386789,0.0001587417,0.000009401854,0.000001717928,0.00003359194,0.000007161734,0.0000425408,0.9991245,0.00002352658,0.00002515225,0.0005009103],"study_design_scores_gemma":[0.00007607627,0.0008709267,0.003894915,0.000009194249,0.00003405526,0.001419423,0.00004382071,0.002075632,0.9872994,0.00005615422,0.004215071,0.000005463197],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938969,0.0002878819,0.004033898,0.00004365447,0.00002849931,0.00007589385,0.0002531154,0.00008315794,0.001296924],"genre_scores_gemma":[0.9910951,0.0003200435,0.00414229,0.00006904462,0.00001838152,0.00009653776,0.0009865045,0.00003165546,0.003240382],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00204827,"threshold_uncertainty_score":0.00685221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04324980804223668,"score_gpt":0.2753075742134235,"score_spread":0.2320577661711868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}