{"id":"W3035340774","doi":"10.1136/annrheumdis-2020-eular.3138","title":"FRI0575 BIOMARKER ANALYSIS FROM THE RISE-SSC STUDY OF RIOCIGUAT IN EARLY DIFFUSE CUTANEOUS SYSTEMIC SCLEROSIS (DCSSC)","year":2020,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Riociguat; Medicine; Placebo; Internal medicine; Clinical endpoint; Biomarker; Gastroenterology; C-reactive protein; Fibrosis; Inflammation; Pathology; Chronic thromboembolic pulmonary hypertension; Pulmonary hypertension; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008264501,0.0006290609,0.0008535897,0.0008864263,0.0004064901,0.001405886,0.0005980013,0.0007316529,0.001958642],"category_scores_gemma":[0.001537844,0.0002404069,0.0007918865,0.000860913,0.0002452797,0.0003725004,0.0005595475,0.0006935816,0.0004731601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006003229,"about_ca_system_score_gemma":0.000362218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003742189,"about_ca_topic_score_gemma":0.006504769,"domain_scores_codex":[0.9993924,0.0001260818,0.00006774787,0.0001804664,0.0001397657,0.00009348056],"domain_scores_gemma":[0.9994281,0.0001120845,0.0001575275,0.00007464212,0.0001322724,0.00009545024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01066733,0.0003144923,0.919284,0.0004669853,0.003606216,0.00089932,0.0001627456,0.0004982041,0.01181554,0.0003638835,0.004264804,0.04765654],"study_design_scores_gemma":[0.0002730217,0.0006806433,0.9879286,0.00008551781,0.00176499,0.001207339,0.0001234382,0.0003530287,0.001449956,0.0002632539,0.005840123,0.00003011193],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9766304,0.0131484,0.0003897333,0.0004345365,0.0001107273,0.00006821737,0.004869229,0.00007413179,0.004274595],"genre_scores_gemma":[0.9956272,0.0007943665,0.0004242169,0.0003211386,0.00005653673,0.00002942243,0.002129774,0.0000157967,0.0006015271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003742189,"threshold_uncertainty_score":0.007440805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0835263571329782,"score_gpt":0.2899377659912241,"score_spread":0.2064114088582459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}