{"id":"W3035342290","doi":"10.1503/cmaj.191231","title":"Immune checkpoint inhibitors in cancer immunotherapy","year":2020,"lang":"en","type":"article","venue":"Canadian Medical Association Journal","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Cytotoxic T cell; Immune system; Immunotherapy; Immune checkpoint; CTLA-4; Programmed cell death; Cancer immunotherapy; Cancer research; PD-L1; Immunology; Immune receptor; Medicine; T cell; Biology; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003529941,0.000363183,0.0004537148,0.000426453,0.0001946795,0.000601661,0.0002932134,0.0006733808,0.003730589],"category_scores_gemma":[0.0002511042,0.0001025492,0.0002475775,0.0003559038,0.0002551497,0.0004060337,0.0003317492,0.001908113,0.0008700299],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008326303,"about_ca_system_score_gemma":0.0006561905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00121023,"about_ca_topic_score_gemma":0.003846287,"domain_scores_codex":[0.9998859,0.00001782607,0.000006063824,0.00001649617,0.00004435625,0.00002927458],"domain_scores_gemma":[0.9999183,0.00002127179,0.00002134366,0.000003465715,0.00001809579,0.00001741484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007297597,0.0003318659,0.000877304,0.001347157,0.00007748736,0.0004245143,0.00005448741,0.001985564,0.023427,0.03227017,0.04380547,0.8946693],"study_design_scores_gemma":[0.000634536,0.001500211,0.002816275,0.0009695109,0.0001048021,0.001794426,0.00004605282,0.001741033,0.0116473,0.01187751,0.9668386,0.00002960974],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01804847,0.9364367,0.002335356,0.01002868,0.002296113,0.00005998866,0.0001522228,0.0001187942,0.03052381],"genre_scores_gemma":[0.202969,0.7444019,0.004230792,0.007602209,0.002946881,0.0001278305,0.0003507053,0.00003861685,0.037332],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003730589,"threshold_uncertainty_score":0.01248008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01202354094226478,"score_gpt":0.2621466733728709,"score_spread":0.2501231324306061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}