{"id":"W3035356494","doi":"10.1016/j.eururo.2020.04.061","title":"Five-year Survival Prediction and Safety Outcomes with Enzalutamide in Men with Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer from the PREVAIL Trial","year":2020,"lang":"en","type":"article","venue":"European Urology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":163,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Pfizer","keywords":"Enzalutamide; Medicine; Hazard ratio; Prostate cancer; Placebo; Internal medicine; Docetaxel; Adverse effect; Confidence interval; Chemotherapy; Oncology; Cabazitaxel; Proportional hazards model; Survival analysis; Incidence (geometry); Urology; Surgery; Cancer; Androgen deprivation therapy; Pathology; Androgen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002959963,0.0001744389,0.0003152637,0.00003277501,0.00007833986,0.00002687333,0.00008160801,0.00002285404,0.0001033914],"category_scores_gemma":[0.0000512945,0.00008855024,0.00002681165,0.0001562783,0.0001945664,0.00006536054,0.00003301564,0.0002599871,0.000009842676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004925585,"about_ca_system_score_gemma":0.0001734626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003963471,"about_ca_topic_score_gemma":0.0004441387,"domain_scores_codex":[0.9984583,0.0004494301,0.0002429181,0.0003628177,0.0002427237,0.0002438713],"domain_scores_gemma":[0.9993708,0.0002026753,0.00008575895,0.0001740738,0.0000535555,0.0001131895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.45373,0.000259272,0.5216626,0.00008090278,0.001312501,0.0007790957,0.01355154,0.000272611,0.002483151,0.00006958687,0.001017972,0.00478083],"study_design_scores_gemma":[0.09582329,0.004441381,0.8942325,0.00003833585,0.000283745,0.000009238256,0.0009152637,0.0002953784,0.0001460948,0.00001494483,0.003663623,0.0001362545],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9722863,0.0005781579,0.0000291404,0.02297964,0.00004430836,0.001605545,0.0001895452,0.00004191367,0.002245442],"genre_scores_gemma":[0.9972901,0.0005660765,0.0001408206,0.0009974575,0.0001705126,0.00006326239,0.0000938172,0.00004312353,0.0006348417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3725699,"threshold_uncertainty_score":0.3610974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02799198590049193,"score_gpt":0.2827059940051615,"score_spread":0.2547140081046696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}