{"id":"W3035385671","doi":"10.1016/j.isci.2020.101259","title":"Selective Quadruple C(sp3)-F Functionalization of Polyfluoroalkyl Ketones","year":2020,"lang":"en","type":"article","venue":"iScience","topic":"Fluorine in Organic Chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Education and Child Care","funders":"Nanjing Tech University; Natural Science Foundation of Jiangsu Province; National Natural Science Foundation of China","keywords":"Chemistry; Surface modification; Combinatorial chemistry; Benzofuran; Catalysis; Heteronuclear molecule; Furan; Context (archaeology); Nucleophile; Amination; Organic chemistry; Nuclear magnetic resonance spectroscopy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002111965,0.0001024107,0.00013039,0.00002575247,0.0001180395,0.000007420588,0.0002755523,0.0001090665,0.001998379],"category_scores_gemma":[0.0003568667,0.0001022863,0.0000421601,0.000569862,0.0002690419,0.0001216674,0.00008581645,0.0002485886,0.0001186719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003926002,"about_ca_system_score_gemma":0.0001467392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001494011,"about_ca_topic_score_gemma":0.000001998419,"domain_scores_codex":[0.9990644,0.00006292262,0.0002126108,0.0002705439,0.0001902171,0.0001992546],"domain_scores_gemma":[0.9993647,0.0001587532,0.0001085386,0.0001026081,0.0001220605,0.0001432839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007496717,0.00007813872,0.0213367,0.00004074192,0.00002059924,0.00000290427,0.00100713,0.0005686757,0.9628053,0.0009304606,0.009569351,0.003565016],"study_design_scores_gemma":[0.0003751431,0.0000822881,0.005942243,0.000004434402,0.00002390358,0.000009759158,0.0001472764,0.005387827,0.9480043,0.0002125764,0.03968055,0.0001296871],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9740028,0.001065271,0.002107036,0.004991096,0.0007828554,0.0001984382,0.00003724335,0.0001437405,0.01667151],"genre_scores_gemma":[0.9971429,0.0000308533,0.0002603702,0.001541648,0.0002205073,0.000007588469,0.000006973809,0.000009165436,0.0007799987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0301112,"threshold_uncertainty_score":0.9989139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1046097250630918,"score_gpt":0.4042692713457887,"score_spread":0.2996595462826969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}