{"id":"W3035387090","doi":"10.3389/fendo.2020.00351","title":"NAMPT and BMAL1 Are Independently Involved in the Palmitate-Mediated Induction of Neuroinflammation in Hypothalamic Neurons","year":2020,"lang":"en","type":"article","venue":"Frontiers in Endocrinology","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Banting and Best Diabetes Centre, University of Toronto; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Nicotinamide phosphoribosyltransferase; Endocrinology; Internal medicine; Neuroinflammation; PER2; Circadian rhythm; Circadian clock; Biology; Downregulation and upregulation; NAD+ kinase; CLOCK; Cell biology; Chemistry; Inflammation; Medicine; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001236526,0.0003163998,0.0003621006,0.0002106843,0.0002118942,0.0003243347,0.000219326,0.0002345686,0.0009654661],"category_scores_gemma":[0.0001201698,0.0001537029,0.0004128652,0.0001808406,0.00032293,0.0003686457,0.0003265855,0.000687362,0.000269463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003156532,"about_ca_system_score_gemma":0.0001886673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000619152,"about_ca_topic_score_gemma":0.001184446,"domain_scores_codex":[0.9998406,0.00001461734,0.00001837672,0.00004447602,0.00003611236,0.00004576599],"domain_scores_gemma":[0.9998828,0.000007255251,0.00004358323,0.00001530027,0.00001472983,0.00003623591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003994181,0.00001051703,0.0003333307,0.00005871785,0.000006890251,0.00005512598,0.00001903085,0.00001604358,0.998457,0.00003637293,0.00001149514,0.0005960056],"study_design_scores_gemma":[0.00002827836,0.0002064089,0.028063,0.00001822511,0.00004176713,0.0005263665,0.0001375259,0.0004527002,0.9685807,0.0001297873,0.001804829,0.00001034468],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919173,0.003420781,0.002697371,0.0001187027,0.00004890908,0.00002457341,0.0007521088,0.00005922748,0.0009610063],"genre_scores_gemma":[0.992953,0.001427175,0.002670556,0.00008828793,0.00001304069,0.00007498761,0.0006609359,0.00002669877,0.002085281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009654661,"threshold_uncertainty_score":0.003229856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03378141309597418,"score_gpt":0.2320356970506452,"score_spread":0.198254283954671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}