{"id":"W3035392729","doi":"10.1158/2326-6074.tumimm18-b15","title":"Abstract B15: The oral Chk1 inhibitor, SRA737, synergizes with immune checkpoint blockade in small-cell lung cancer (SCLC)","year":2020,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Positive Living Society of British Columbia","funders":"","keywords":"Immune checkpoint; Cancer research; Immunotherapy; Cancer; CHEK1; Immune system; In vivo; Blockade; Medicine; Lung cancer; T cell; Cancer immunotherapy; Immunology; Biology; Cell cycle checkpoint; Cell cycle; Oncology; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003010847,0.0007637806,0.0009849656,0.0005516144,0.0002928924,0.0003894973,0.0004218137,0.0005787323,0.003285028],"category_scores_gemma":[0.0001769659,0.0001728107,0.0005702981,0.0004038794,0.0002882341,0.0002393174,0.0002111736,0.001142687,0.0007937797],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003905043,"about_ca_system_score_gemma":0.001086283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001439016,"about_ca_topic_score_gemma":0.003852012,"domain_scores_codex":[0.9998166,0.00003816855,0.00001796666,0.0000202581,0.00003950338,0.00006752727],"domain_scores_gemma":[0.9998606,0.00002389598,0.00002215177,0.00001182294,0.00001249478,0.00006892504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0356871,0.013721,0.002602953,0.001245218,0.0005379818,0.0006653542,0.00008891006,0.001911696,0.7992964,0.0005292532,0.005472676,0.1382415],"study_design_scores_gemma":[0.01541724,0.2245499,0.03338514,0.0001272829,0.0009823424,0.001634114,0.000120467,0.005671837,0.7051335,0.0002368391,0.01268005,0.0000613806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989328,0.004676608,0.0005323573,0.000331465,0.0001591021,0.0003602285,0.0007191965,0.0003169377,0.003576043],"genre_scores_gemma":[0.9949688,0.001545187,0.0005696735,0.0001588211,0.00006245064,0.0001644265,0.0008853005,0.00001656969,0.001628661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003285028,"threshold_uncertainty_score":0.01098949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0738198577910945,"score_gpt":0.3948078948909215,"score_spread":0.320988037099827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}