{"id":"W3035408975","doi":"10.1038/s41392-020-0187-x","title":"The mechanisms of sorafenib resistance in hepatocellular carcinoma: theoretical basis and therapeutic aspects","year":2020,"lang":"en","type":"review","venue":"Signal Transduction and Targeted Therapy","topic":"Hepatocellular Carcinoma Treatment and Prognosis","field":"Medicine","cited_by":1132,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Sorafenib; Hepatocellular carcinoma; Resistance (ecology); Medicine; Oncology; Bioinformatics; Internal medicine; Cancer research; Computational biology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004019548,0.0004861525,0.001438981,0.0001731324,0.0001492085,0.00003574887,0.0001113726,0.0003189012,0.0002017276],"category_scores_gemma":[0.00001006298,0.0003014674,0.000407952,0.0004836381,0.0004060756,0.00003571783,0.00001218003,0.0004901107,0.000003268657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005104807,"about_ca_system_score_gemma":0.0002035778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001208475,"about_ca_topic_score_gemma":0.000006079937,"domain_scores_codex":[0.9977271,0.0004676162,0.000636398,0.0005438469,0.0003098916,0.000315177],"domain_scores_gemma":[0.9990881,0.0002424416,0.0001763716,0.0002544208,0.0000596366,0.0001790383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001131135,0.0002758131,0.001406289,0.004965956,0.001032131,0.0002999823,0.0009018878,2.141599e-8,0.0008500286,0.09141394,0.00001029939,0.8977125],"study_design_scores_gemma":[0.008284951,0.002678805,0.0005172527,0.005433303,0.003787639,0.0003450739,0.000431391,0.000500362,0.01338042,0.07384063,0.8893759,0.001424256],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003159391,0.9937254,0.0002792071,0.00076883,0.00009018378,0.001699863,0.00002879729,0.00003821407,0.0002100668],"genre_scores_gemma":[0.3958434,0.6037465,0.0001171821,0.00003964747,0.0000546272,0.0000950509,0.00003142935,0.00004373865,0.00002836546],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8962883,"threshold_uncertainty_score":0.9999437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05311660016790334,"score_gpt":0.2674391736520976,"score_spread":0.2143225734841942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}