{"id":"W3035424962","doi":"10.18388/abp.2020_5226","title":"Excessive amount and activity of μ-calpain affects apoptotic machinery in chronic B-cell leukemia cells and influences the course of the disease","year":2020,"lang":"en","type":"article","venue":"Acta Biochimica Polonica","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Gdański Uniwersytet Medyczny","keywords":"Calpain; Chronic lymphocytic leukemia; Apoptosis; CD19; Leukemia; Proteases; Intracellular; Immunology; Cancer research; Disease; B cell; Medicine; Biology; Chemistry; Internal medicine; Cell biology; Immune system; Enzyme; Biochemistry; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001419408,0.0001175356,0.0001347648,0.0000158347,0.00005889441,0.000009907988,0.0001452776,0.00008690816,0.000003802439],"category_scores_gemma":[0.00008381355,0.0000694804,0.00006044069,0.0001033586,0.0004022249,0.000005593163,0.0001730324,0.0001186936,2.226863e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002059692,"about_ca_system_score_gemma":0.000256688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005141041,"about_ca_topic_score_gemma":0.00004939117,"domain_scores_codex":[0.9992326,0.0001810666,0.0001454404,0.0002277628,0.00009199612,0.0001210841],"domain_scores_gemma":[0.9994416,0.00005632036,0.0001729452,0.0002317213,0.00001938014,0.00007809763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001930936,0.00003829953,0.002766974,0.0001158743,0.00001985207,3.655786e-7,0.00008332877,0.0001589775,0.9958115,0.00001210706,0.0003375704,0.0004620834],"study_design_scores_gemma":[0.0007265112,0.0002222846,0.1829249,0.00004492947,0.00004813197,0.000001847994,0.00004938386,0.002640807,0.812331,0.00002241835,0.0008665271,0.0001211996],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994709,0.001241228,0.00001937143,0.00362452,0.00004075898,0.0003026768,0.0000312277,0.000003600044,0.00002760213],"genre_scores_gemma":[0.9992715,0.0003133611,0.00001215751,0.0003004324,0.00005520114,0.000009874047,0.000007495958,0.000008370999,0.00002157171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1834804,"threshold_uncertainty_score":0.2833328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005990919738793915,"score_gpt":0.2213844614889734,"score_spread":0.2153935417501795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}