{"id":"W3035432557","doi":"10.1101/2020.06.09.141812","title":"<i>Dmp1Cre</i> -directed knockdown of PTHrP in murine decidua is associated with increased bone width and a life-long increase in strength specific to male progeny","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"National Health and Medical Research Council; Medical Research Council; State Government of Victoria; University of Melbourne","keywords":"Gene knockdown; Endocrinology; Decidua; Internal medicine; Osteopenia; Embryonic stem cell; Weaning; Biology; Andrology; Gene; Bone mineral; Medicine; Fetus; Pregnancy; Genetics; Osteoporosis; Placenta","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002318077,0.0004406176,0.0002347631,0.0005946833,0.0002466245,0.0003682047,0.0003754022,0.0003688986,0.003022242],"category_scores_gemma":[0.0001135564,0.0003741757,0.0002708079,0.0001921416,0.0005215339,0.0002033595,0.0003429093,0.000947114,0.001064137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003889567,"about_ca_system_score_gemma":0.0001653339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005120821,"about_ca_topic_score_gemma":0.001000511,"domain_scores_codex":[0.9996718,0.00003626715,0.00003948727,0.0001014152,0.0000829058,0.00006812294],"domain_scores_gemma":[0.9996699,0.00004426571,0.0001246664,0.00003451042,0.00001808017,0.0001085703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005328035,0.000009620926,0.0001153724,0.00001683425,0.000001653339,0.00004617318,0.000009566333,0.00001276149,0.9991478,0.00008644436,0.0000511167,0.0004494188],"study_design_scores_gemma":[0.00001495954,0.00009411701,0.004785985,0.000008163637,0.000007964175,0.000388721,0.00002286201,0.0002363442,0.9918939,0.00003289858,0.002510145,0.000003816802],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786602,0.001862533,0.01017597,0.0003611269,0.000101081,0.00006778798,0.003324186,0.0006836596,0.004763521],"genre_scores_gemma":[0.9693786,0.0009426173,0.00898038,0.0002361171,0.00003510407,0.0001944025,0.002770198,0.0004054241,0.01705707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003022242,"threshold_uncertainty_score":0.01011044,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01374662706019395,"score_gpt":0.2111066864400033,"score_spread":0.1973600593798093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}