{"id":"W3035475906","doi":"10.1016/j.molcel.2020.05.025","title":"Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution","year":2020,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval; Centre hospitalier universitaire de Québec","funders":"RIKEN; European Research Council; Fonds de Recherche du Québec - Santé; Associazione Italiana per la Ricerca sul Cancro; Centre National de la Recherche Scientifique; Ligue Contre le Cancer; Institut National Du Cancer; Ludwig Institute for Cancer Research; Institut National de la Santé et de la Recherche Médicale; NIHR Oxford Biomedical Research Centre; Wellcome Trust; Agence Nationale de la Recherche; Háskóli Íslands; L'Oreal USA; Fondazione Cariplo; Cancer Research UK; Harry J. Lloyd Charitable Trust; Melanoma Research Alliance; Medical Research Council; Cancer Research Society","keywords":"Biology; Transcription factor; Microphthalmia-associated transcription factor; Sp3 transcription factor; CREB; General transcription factor; E-box; Activating transcription factor 2; Cell biology; IRF4; Enhancer; Molecular biology; Genetics; Promoter; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001382493,0.0001937145,0.0002092684,0.00023267,0.0001487056,0.0003758468,0.000336246,0.0001913224,0.001491294],"category_scores_gemma":[0.0002041578,0.0002007108,0.0001280992,0.0001131864,0.0003035887,0.000309366,0.0003209509,0.0003688958,0.0003309557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003415193,"about_ca_system_score_gemma":0.0001398901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003546354,"about_ca_topic_score_gemma":0.0009980705,"domain_scores_codex":[0.9998777,0.00001312821,0.000006275536,0.00004890868,0.00003004253,0.0000238714],"domain_scores_gemma":[0.9998686,0.00003524166,0.00003631984,0.00002010637,0.00001138765,0.00002820011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000234796,0.00000389808,0.0002088957,0.000006669958,0.000001378551,0.000008810736,0.000003872551,0.00005768392,0.99907,0.0001300028,0.000008295524,0.0004770893],"study_design_scores_gemma":[0.00001059536,0.00009836495,0.007189417,0.000003151457,0.0000099197,0.0001668381,0.00002541503,0.003464276,0.9871202,0.0002736918,0.001630168,0.000008118631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889984,0.0008610846,0.008392367,0.00008693279,0.00001546447,0.000009168164,0.0001281028,0.0001843218,0.001324246],"genre_scores_gemma":[0.9977314,0.00018495,0.001355111,0.0000236571,0.000005683673,0.00000712172,0.00007497396,0.0000242836,0.0005927567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001491294,"threshold_uncertainty_score":0.004988909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01067563419856611,"score_gpt":0.2068054044442742,"score_spread":0.1961297702457081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}