{"id":"W3035475906","doi":"10.1016/j.molcel.2020.05.025","title":"Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution","year":2020,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval; Centre hospitalier universitaire de Québec","funders":"RIKEN; European Research Council; Fonds de Recherche du Québec - Santé; Associazione Italiana per la Ricerca sul Cancro; Centre National de la Recherche Scientifique; Ligue Contre le Cancer; Institut National Du Cancer; Ludwig Institute for Cancer Research; Institut National de la Santé et de la Recherche Médicale; NIHR Oxford Biomedical Research Centre; Wellcome Trust; Agence Nationale de la Recherche; Háskóli Íslands; L'Oreal USA; Fondazione Cariplo; Cancer Research UK; Harry J. Lloyd Charitable Trust; Melanoma Research Alliance; Medical Research Council; Cancer Research Society","keywords":"Biology; Transcription factor; Microphthalmia-associated transcription factor; Sp3 transcription factor; CREB; General transcription factor; E-box; Activating transcription factor 2; Cell biology; IRF4; Enhancer; Molecular biology; Genetics; Promoter; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006507397,0.0001768643,0.0001370025,0.00001122575,0.00007739153,0.0000310755,0.0001768277,0.000178307,0.00005980197],"category_scores_gemma":[0.00005041502,0.0001986498,0.0001267455,0.00009577067,0.00004440708,0.000005826601,0.00006304467,0.0001177629,0.00005620594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003921428,"about_ca_system_score_gemma":0.000065955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006922252,"about_ca_topic_score_gemma":0.000003175938,"domain_scores_codex":[0.9989157,0.00006363344,0.0002509586,0.0004193789,0.0001227814,0.0002275235],"domain_scores_gemma":[0.9994546,0.000005188077,0.00009469877,0.0002714935,0.00006655965,0.0001074836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003347541,0.00003171573,0.0003369683,0.00002842335,0.0000190972,0.000003470205,0.0002137743,0.0004077457,0.9984643,0.00004671167,0.00025107,0.0001632406],"study_design_scores_gemma":[0.001030037,0.0002787648,0.001466233,0.000005309197,0.00003531919,0.000002946892,0.0001382312,0.01101135,0.9607687,0.0001561649,0.02469775,0.0004092039],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.889878,0.0003985459,0.1075295,0.0003473462,0.00008172349,0.0002098455,0.0001199071,0.00003078812,0.001404315],"genre_scores_gemma":[0.9957793,0.0000652059,0.001738947,0.0006080787,0.00009054681,0.000009237551,0.001635904,0.0000313185,0.00004143594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1059013,"threshold_uncertainty_score":0.8100705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01067563419856611,"score_gpt":0.2068054044442742,"score_spread":0.1961297702457081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}