{"id":"W3035496509","doi":"10.1158/1078-0432.ccr-20-0224","title":"<i>ESR1</i> Mutations and Overall Survival on Fulvestrant versus Exemestane in Advanced Hormone Receptor–Positive Breast Cancer: A Combined Analysis of the Phase III SoFEA and EFECT Trials","year":2020,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":158,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"National Institute for Health and Care Research; Cancer Research UK; AstraZeneca","keywords":"Fulvestrant; Exemestane; Oncology; Breast cancer; Medicine; Internal medicine; Hormone receptor; Estrogen receptor; Oestrogen receptor; Cancer; Aromatase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002543433,0.0002469872,0.001592029,0.0002313059,0.0001459854,0.00002702932,0.0002068719,0.0001462723,0.0001766702],"category_scores_gemma":[0.001660861,0.0001754534,0.0003008241,0.001858082,0.001042447,0.0001226445,0.0001427642,0.001023426,0.000001373476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002573758,"about_ca_system_score_gemma":0.0006120249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009857628,"about_ca_topic_score_gemma":0.000816708,"domain_scores_codex":[0.9954967,0.001343754,0.001097868,0.0007282161,0.0008576406,0.0004757965],"domain_scores_gemma":[0.9937202,0.004710219,0.0003152068,0.0003927729,0.0004458621,0.0004157047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5414643,0.002169677,0.07550047,0.0003115091,0.006865925,0.00008856709,0.003148191,0.001191832,0.05446593,0.0007898055,0.0004198866,0.3135839],"study_design_scores_gemma":[0.151529,0.00911658,0.8264967,0.0007861182,0.002459199,0.000005588662,0.001549572,0.002459398,0.003470085,0.0002697023,0.001331125,0.0005269199],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9779891,0.003020388,0.00004176344,0.01621478,0.0002118139,0.001432048,0.0009639049,0.00002455979,0.0001015966],"genre_scores_gemma":[0.992815,0.005997189,0.00009464566,0.0004856441,0.0002264031,0.0002436337,0.00004773264,0.00003396296,0.00005582886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7509962,"threshold_uncertainty_score":0.7154784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2207194958004969,"score_gpt":0.5247294331244319,"score_spread":0.304009937323935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}