{"id":"W3035542047","doi":"10.1136/rmdopen-2020-001184","title":"Autoantigen <i>TRIM21</i>/Ro52 is expressed on the surface of antigen-presenting cells and its enhanced expression in Sjögren’s syndrome is associated with B cell hyperactivity and type I interferon activity","year":2020,"lang":"en","type":"article","venue":"RMD Open","topic":"Salivary Gland Disorders and Functions","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Arthritis Society; Dutch Arthritis Society; GlaxoSmithKline","keywords":"Autoantibody; Immune system; Antigen; Autoimmunity; Cell; Immunology; Medicine; Cell type; Antibody; Downregulation and upregulation; Cell biology; Biology; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001993714,0.0001735529,0.0004117361,0.00003664073,0.0001257813,0.0000655331,0.0001451779,0.00009198196,0.0001539322],"category_scores_gemma":[0.0001090851,0.0001152657,0.00002981851,0.0002692326,0.00004478299,0.0002280906,0.0002313146,0.0002563398,0.000007522234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001729013,"about_ca_system_score_gemma":0.0000749793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000246147,"about_ca_topic_score_gemma":0.00002701666,"domain_scores_codex":[0.9989185,0.0001264848,0.0001731019,0.0003831295,0.0001997217,0.0001990108],"domain_scores_gemma":[0.9991668,0.0002889985,0.0001541742,0.0002206373,0.00006522295,0.0001041252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001552359,0.0003733244,0.06811115,0.0000990611,0.00005551035,0.00002319116,0.003090201,0.00002115192,0.9255529,0.000001436945,0.0009670075,0.0001526923],"study_design_scores_gemma":[0.002534521,0.0007601903,0.1792036,0.0003315389,0.00004398307,0.000003270218,0.0005072355,0.001489563,0.8147798,0.000007733095,0.0001744761,0.0001640814],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995338,0.0001839274,0.00002915226,0.001373752,0.00004428821,0.0007784995,0.00004387536,0.00001929255,0.002189279],"genre_scores_gemma":[0.998857,0.0002212524,0.00004441865,0.0005450451,0.00001082114,0.000008737392,0.000008420913,0.0000217188,0.0002826474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1110924,"threshold_uncertainty_score":0.4700401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04192789554148402,"score_gpt":0.2738912289501956,"score_spread":0.2319633334087116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}