{"id":"W3035584768","doi":"10.1101/2020.06.15.153072","title":"PKIS Deep Dive Yields a Chemical Starting Point for Dark Kinases and a Cell Active BRSK2 Inhibitor","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Novartis Pharma; Gillings School of Public Health; Genentech; National Institutes of Health; Ministero dello Sviluppo Economico; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Ontario Ministry of Economic Development and Innovation; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; North Carolina Biotechnology Center; GlaxoSmithKline; Pfizer","keywords":"Kinome; Druggability; Kinase; Drug discovery; Computational biology; Phosphorylation; Chemistry; Computer science; Biology; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005433187,0.0006118448,0.0007414268,0.0005229269,0.000430185,0.001184619,0.0004438952,0.0005487791,0.009183406],"category_scores_gemma":[0.0004183011,0.0004004622,0.0005814853,0.0004213582,0.000425014,0.0004896167,0.0009272083,0.00189022,0.004780267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006150426,"about_ca_system_score_gemma":0.0008339182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007134648,"about_ca_topic_score_gemma":0.001698872,"domain_scores_codex":[0.9996231,0.00002905403,0.00002406046,0.00007437484,0.0001801596,0.00006928247],"domain_scores_gemma":[0.9998247,0.00003016853,0.00002473805,0.00003898501,0.00003502471,0.00004635457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003992863,0.0001022634,0.0003627515,0.0003323725,0.00003813638,0.0002139834,0.00005382443,0.001685312,0.9740196,0.002055038,0.003162468,0.01757495],"study_design_scores_gemma":[0.00004801274,0.0003193981,0.000561602,0.00002549405,0.00002405685,0.0002202471,0.00002713628,0.001306011,0.9679317,0.000468663,0.02904799,0.00001976329],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7396195,0.01053988,0.1314012,0.002853195,0.0009163392,0.0009791831,0.03525667,0.008304166,0.07012989],"genre_scores_gemma":[0.8420482,0.005801467,0.07469003,0.001100914,0.00006663772,0.0004266126,0.02739997,0.001685778,0.04678037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009183406,"threshold_uncertainty_score":0.03072155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008559042155874505,"score_gpt":0.2358188946238464,"score_spread":0.2272598524679719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}