{"id":"W3035637693","doi":"10.1101/2020.06.10.145342","title":"Binding of <i>Leishmania infantum</i> LPG to the midgut is not sufficient to define vector competence in <i>Lutzomyia longipalpis</i> sand flies","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Midgut; Leishmania infantum; Biology; Leishmania; Visceral leishmaniasis; Microbiology; Lipophosphoglycan; Mutant; Parasite hosting; Psychodidae; Vector (molecular biology); Leishmaniasis; Immunology; Larva; Ecology; Leishmania donovani; Biochemistry; Gene; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006931781,0.0003190284,0.0001878026,0.0001482029,0.0001192034,0.000308115,0.00020572,0.0002697437,0.001226936],"category_scores_gemma":[0.00008642898,0.0001890037,0.0002089104,0.00007716759,0.0001908989,0.0001445108,0.0002850713,0.0006485815,0.0004306211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003829311,"about_ca_system_score_gemma":0.0001349964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002673876,"about_ca_topic_score_gemma":0.003799024,"domain_scores_codex":[0.9998428,0.00002058981,0.00001656862,0.00002899292,0.00004443083,0.00004664454],"domain_scores_gemma":[0.9998617,0.000022182,0.00004766669,0.00001614912,0.00001581578,0.00003646049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001915627,0.00001004144,0.0001776681,0.00001089829,0.000001599201,0.0000112954,0.000006674915,0.000008779301,0.9996075,0.00001386871,0.000009122666,0.0001233722],"study_design_scores_gemma":[0.000006981667,0.0003333729,0.02415442,0.000008241074,0.00001207706,0.0002057347,0.00009813272,0.000704905,0.9729981,0.00001470964,0.001457312,0.000006081811],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980826,0.0002479537,0.0005285498,0.00003163135,0.000007986537,0.00001897476,0.0003362126,0.00002670718,0.0007193156],"genre_scores_gemma":[0.995313,0.0001708377,0.001035498,0.0000476004,0.000002982257,0.00002397387,0.001121656,0.00002005028,0.002264336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002673876,"threshold_uncertainty_score":0.005316615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03008350183671659,"score_gpt":0.2664875658349156,"score_spread":0.236404063998199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}