{"id":"W3035687571","doi":"10.3390/bioengineering7020056","title":"Modulation of the Microtubule Network for Optimization of Nanoparticle Dynamics for the Advancement of Cancer Nanomedicine","year":2020,"lang":"en","type":"article","venue":"Bioengineering","topic":"Radiation Therapy and Dosimetry","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of Victoria","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; University of Victoria","keywords":"Docetaxel; Nanomedicine; Microtubule; Nanoparticle; Cancer cell; Chemistry; Biophysics; Radiation therapy; Intracellular; Nanotechnology; Nucleus; Materials science; Cancer research; Cancer; Cell biology; Biochemistry; Medicine; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008010741,0.00004458936,0.0001207188,0.00001259734,0.00002113025,8.99927e-7,0.0000445477,0.00002025553,0.000007911297],"category_scores_gemma":[0.0000499827,0.0000280376,0.00005275843,0.0001746223,0.00002048632,0.0000192346,0.000006830314,0.00001719866,2.05067e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002288226,"about_ca_system_score_gemma":0.00002014431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007518649,"about_ca_topic_score_gemma":0.000001947624,"domain_scores_codex":[0.9995997,0.000003582569,0.0002038551,0.00005453109,0.00007101263,0.0000673347],"domain_scores_gemma":[0.9996401,0.00006593055,0.0001115026,0.00009001301,0.00007463381,0.00001783949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001310384,0.00001242992,0.002152306,0.0002115913,0.00004877006,6.671729e-9,0.0001229243,0.8794078,0.1145487,0.0004474563,0.00003506899,0.002881871],"study_design_scores_gemma":[0.0008062562,0.0001416946,0.004348618,0.00006815736,0.00005997792,1.070741e-7,0.00003489384,0.8948027,0.0991038,0.000005461143,0.0006045141,0.000023833],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1579688,0.001824965,0.8356371,0.003502683,0.0001924231,0.0008239175,0.00003845928,0.000009019414,0.00000260499],"genre_scores_gemma":[0.9917146,0.0001277696,0.007858288,0.0001009594,0.0001165884,0.00004201014,0.00001081175,0.000009709131,0.0000192801],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.8337458,"threshold_uncertainty_score":0.114334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01517479411564206,"score_gpt":0.2603063562684827,"score_spread":0.2451315621528407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}