{"id":"W3035712898","doi":"10.1093/nar/gkaa501","title":"ATAD5 restricts R-loop formation through PCNA unloading and RNA helicase maintenance at the replication fork","year":2020,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Institute for Basic Science; Canadian Institutes of Health Research; Ulsan National Institute of Science and Technology; Canadian Cancer Society","keywords":"Biology; Helicase; Replisome; Minichromosome maintenance; DNA replication; Transcription (linguistics); Control of chromosome duplication; Cell biology; Origin recognition complex; Genetics; RNA; Gene; Eukaryotic DNA replication","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000812277,0.0001154815,0.0001024481,0.00002743882,0.0004086063,0.0000728304,0.0003457643,0.0001396464,0.00002486604],"category_scores_gemma":[0.001006648,0.00009188017,0.000048582,0.0003136618,0.0001681764,0.00002365967,0.0006333455,0.0002435645,0.0001067109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006327854,"about_ca_system_score_gemma":0.000046593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002059736,"about_ca_topic_score_gemma":0.00001214419,"domain_scores_codex":[0.9982853,0.0001868364,0.000208529,0.0005297513,0.0003878214,0.000401753],"domain_scores_gemma":[0.9987815,0.00005243237,0.0000676288,0.0007833284,0.0001863668,0.0001287452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001674945,0.00001410906,0.0001083893,0.00004318221,0.00001307531,0.000006465119,0.000344093,0.000005805203,0.967126,0.001025549,0.01977477,0.01137109],"study_design_scores_gemma":[0.000509959,0.0004489774,0.0003636328,0.00002210005,0.000007897039,0.00004839044,0.0004774689,0.002116562,0.8579513,0.0006359719,0.1372652,0.0001525093],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854779,0.000647241,0.002677764,0.00672853,0.00003426772,0.0005644546,0.0000224275,0.00003732981,0.003810091],"genre_scores_gemma":[0.9958893,0.0006838736,0.001048062,0.0008908286,0.0001811964,0.00007393356,0.00009204552,0.0000290638,0.001111695],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1174904,"threshold_uncertainty_score":0.3746765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06567299157026524,"score_gpt":0.3380242655818466,"score_spread":0.2723512740115813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}