{"id":"W3035726067","doi":"10.1186/s13059-020-02050-y","title":"Dynamic rewiring of the human interactome by interferon signaling","year":2020,"lang":"en","type":"article","venue":"Genome biology","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Genome Canada; Canadian Institutes of Health Research; Killam Trusts; Genome British Columbia; Northwestern University","keywords":"Interactome; Biology; Interferon; Proteome; Protein–protein interaction; Transcriptome; Computational biology; Interferon-stimulated gene; STAT1; Human proteome project; Signal transduction; Gene regulatory network; Human genetics; Gene; Interaction network; Proteomics; Ribosomal protein; Transcription factor; Cell biology; Genetics; Gene expression; RNA; Receptor; Innate immune system; Ribosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000928786,0.0001159195,0.0001512268,0.00001367387,0.00005811821,0.000008054665,0.0003767389,0.0001373079,0.00003744582],"category_scores_gemma":[0.00001605425,0.00008648435,0.00009246415,0.00005848942,0.0001031294,0.000001845881,0.0003177316,0.0001257447,0.000008060149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000111263,"about_ca_system_score_gemma":0.00001783292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005879656,"about_ca_topic_score_gemma":0.000004983906,"domain_scores_codex":[0.9992608,0.00004193099,0.0002824504,0.0001905505,0.00003288396,0.0001913401],"domain_scores_gemma":[0.9995349,0.000006801662,0.0001480683,0.0002303409,0.00002790855,0.00005200218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002161927,0.000008106033,0.0005327167,0.00001610247,0.00004134526,8.714309e-8,0.0001530776,0.00005518484,0.9979352,0.00008687509,0.0003982005,0.000751477],"study_design_scores_gemma":[0.002373495,0.003504787,0.003550207,0.00008142678,0.0001045615,0.00003118407,0.0007485185,0.00298623,0.6852945,0.002101628,0.2979425,0.001280985],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919427,0.0009715263,0.00568861,0.0004263656,0.0001458142,0.0001277653,0.00005113953,0.000007729543,0.0006383216],"genre_scores_gemma":[0.9985127,0.0000312646,0.0001991845,0.0008762717,0.00009312177,0.000004275398,0.0001549675,0.00001293413,0.0001152323],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3126407,"threshold_uncertainty_score":0.352673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009390371422394846,"score_gpt":0.2378739412549327,"score_spread":0.2284835698325379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}