{"id":"W3035735540","doi":"10.1101/2020.06.15.151456","title":"An Atlas of Phosphorylation and Proteolytic Processing Events During Excitotoxic Neuronal Death Reveals New Therapeutic Opportunities","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Health and Medical Research Council; Natural Sciences and Engineering Research Council of Canada; Medical Research Council; Israel Science Foundation","keywords":"Excitotoxicity; Neuroprotection; Biology; Synaptogenesis; Programmed cell death; Cell biology; Phosphoproteomics; Kinase; Neuroscience; Protein kinase A; Protein phosphorylation; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002565934,0.0006329203,0.0005680521,0.001653645,0.0001824724,0.0006395162,0.0002958863,0.0003837484,0.004652517],"category_scores_gemma":[0.0001725421,0.0001721206,0.000594133,0.001507744,0.0001505775,0.0005428725,0.0003688679,0.000785636,0.001254177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003601524,"about_ca_system_score_gemma":0.0002617567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00030756,"about_ca_topic_score_gemma":0.0004841653,"domain_scores_codex":[0.9998597,0.00001348524,0.00000867186,0.0000338561,0.00005578318,0.00002849746],"domain_scores_gemma":[0.9998668,0.00001214835,0.00005020875,0.00001287387,0.00003275028,0.00002511076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001734396,0.0001148569,0.008682613,0.004108628,0.000450992,0.0007860198,0.0001139936,0.002449322,0.7871899,0.002492077,0.02283421,0.1690431],"study_design_scores_gemma":[0.0001455053,0.001442265,0.1895572,0.0005475566,0.001018468,0.006333693,0.0003441522,0.01192855,0.5330907,0.009449919,0.2459335,0.0002085797],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6263762,0.2250813,0.06681687,0.004375522,0.001328928,0.0003378725,0.04843982,0.003967317,0.02327617],"genre_scores_gemma":[0.8022345,0.1209013,0.02926057,0.001040758,0.0005583728,0.0003084148,0.02908599,0.0003405721,0.0162695],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004652517,"threshold_uncertainty_score":0.01556426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02710265141088626,"score_gpt":0.2387726434422524,"score_spread":0.2116699920313661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}