{"id":"W3035762342","doi":"10.1172/jci.insight.136012","title":"A rational mouse model to detect on-target, off-tumor CAR T cell toxicity","year":2020,"lang":"en","type":"article","venue":"JCI Insight","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Cancer Institute; Breast Cancer Society of Canada; University of Pennsylvania","keywords":"Toxicity; In vivo; Potency; Cancer research; Antigen; Downregulation and upregulation; Cell; Chimeric antigen receptor; Biology; Immunology; Chemistry; Pharmacology; In vitro; T cell; Medicine; Immune system; Internal medicine; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001208124,0.0001909154,0.0003094154,0.0001196048,0.00008099079,0.00003075474,0.0001716255,0.00007814091,0.002316671],"category_scores_gemma":[0.0001643788,0.0001651116,0.0001401187,0.0003054548,0.0000365698,0.00006413323,0.00008656221,0.0003853771,0.000634942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001717032,"about_ca_system_score_gemma":0.0003145246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001459845,"about_ca_topic_score_gemma":0.00001240803,"domain_scores_codex":[0.9982529,0.00005432054,0.0002426481,0.0004224416,0.0006839942,0.0003436549],"domain_scores_gemma":[0.99883,0.00008092161,0.00003718166,0.0003637284,0.0001418391,0.0005462928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001169129,0.0001599389,0.0001016335,0.0000545364,0.00003484119,0.00008584141,0.001495143,0.003135859,0.9746928,0.0000897292,0.01767395,0.001306645],"study_design_scores_gemma":[0.001544909,0.001082036,0.00007712057,0.00001382467,0.00001580639,0.000005848438,0.00003778448,0.0465705,0.8592334,0.00007766067,0.09114897,0.0001921026],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9416358,0.0001608814,0.003260347,0.005957559,0.00007846065,0.001053641,0.00006151135,0.0001521229,0.04763963],"genre_scores_gemma":[0.9573932,0.0000220312,0.003901648,0.01720667,0.0005524005,0.00007403774,0.00002694482,0.00006479648,0.02075825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1154593,"threshold_uncertainty_score":0.9985954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05259355392620244,"score_gpt":0.2997206711491535,"score_spread":0.247127117222951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}