{"id":"W3035773554","doi":"10.1101/2020.06.18.135061","title":"Multiomics Characterization of Potential Therapeutic Vulnerabilities in Low-grade Serous Ovarian Carcinoma","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; London Health Sciences Centre; BC Cancer Agency; University of British Columbia","funders":"University of British Columbia; BC Cancer Agency; Terry Fox Research Institute","keywords":"KRAS; Selumetinib; Neuroblastoma RAS viral oncogene homolog; CDKN2A; Cancer research; Targeted therapy; Serous fluid; Synthetic lethality; Somatic cell; Exome sequencing; Gene; Biology; Mutation; Medicine; Cancer; Mutant; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002976983,0.0002661313,0.000461553,0.001288046,0.0001883697,0.0008200403,0.0002017632,0.0002370691,0.0004868445],"category_scores_gemma":[0.0004940885,0.0001092739,0.0004795422,0.001102634,0.0001404914,0.0002221842,0.0003822953,0.0001868542,0.0001446304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004123797,"about_ca_system_score_gemma":0.0002271902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001815856,"about_ca_topic_score_gemma":0.001958084,"domain_scores_codex":[0.9998714,0.00001697674,0.00001107133,0.00003933494,0.00004242937,0.00001874627],"domain_scores_gemma":[0.9997668,0.00006576543,0.00007695265,0.00002646986,0.0000423482,0.0000217181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009106385,0.0001764982,0.5077476,0.0004288183,0.000550332,0.0008459755,0.0001830399,0.02227402,0.4272285,0.0005222337,0.001217947,0.03791443],"study_design_scores_gemma":[0.0000385755,0.0004486363,0.6713492,0.00004166284,0.0004279646,0.001719202,0.0004763805,0.1745751,0.1440186,0.001664227,0.00518563,0.00005473584],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927654,0.0005359044,0.003014061,0.00005792692,0.000003317313,0.00001815365,0.003120251,0.00009729313,0.0003876594],"genre_scores_gemma":[0.9906532,0.0003067576,0.003746698,0.00003798609,0.000004143809,0.00002477802,0.00503223,0.00001826286,0.0001759553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001815856,"threshold_uncertainty_score":0.003610551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01088734854279279,"score_gpt":0.2105425739173122,"score_spread":0.1996552253745194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}