{"id":"W3035811149","doi":"10.1158/1557-3265.liqbiop20-a09","title":"Abstract A09: Cerebrospinal fluid (CSF) as a source of ctDNA for diagnosis and monitoring of pediatric patients with midline diffuse gliomas","year":2020,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"PDGFRA; Medicine; Liquid biopsy; Digital polymerase chain reaction; Glioma; Biopsy; Pathology; Cerebrospinal fluid; Exome sequencing; DNA sequencing; KRAS; Oncology; Mutation; Internal medicine; Cancer research; Gene; Polymerase chain reaction; Biology; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003898011,0.0004369055,0.0003322817,0.0009708942,0.0002968269,0.0006328292,0.0003431129,0.0004086512,0.0007835078],"category_scores_gemma":[0.001480823,0.0001562682,0.0001849926,0.0004313485,0.0003402669,0.0002910788,0.0002377148,0.0003737308,0.0002919384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004099444,"about_ca_system_score_gemma":0.0004862959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001102378,"about_ca_topic_score_gemma":0.001022121,"domain_scores_codex":[0.99962,0.00007414756,0.0000491066,0.0001214323,0.00009574556,0.00003959468],"domain_scores_gemma":[0.9992445,0.0002376223,0.0001876124,0.00004517687,0.0001707753,0.0001143544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002144304,0.0002107249,0.7317719,0.0003049154,0.00007280303,0.01099685,0.0005086959,0.0006298472,0.1945187,0.0001309088,0.0008007471,0.05790956],"study_design_scores_gemma":[0.0001567085,0.004442008,0.6502101,0.0001688547,0.0002318341,0.04784409,0.0009070744,0.005713332,0.2842221,0.0002064319,0.00583407,0.00006340379],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934417,0.001527939,0.003023258,0.0001535081,0.00002778612,0.0001065112,0.0006773766,0.0001207288,0.0009211798],"genre_scores_gemma":[0.9927924,0.0003321708,0.00599813,0.00008940827,0.00002468596,0.00005212314,0.0004999987,0.00001731253,0.0001936955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001102378,"threshold_uncertainty_score":0.002974391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1929913959235016,"score_gpt":0.4706606073553027,"score_spread":0.2776692114318012,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}