{"id":"W3035840506","doi":"10.1021/acsomega.0c01618","title":"Regulation of Autophagy Progress via Lysosomal Depletion by Fluvastatin Nanoparticle Treatment in Breast Cancer Cells","year":2020,"lang":"en","type":"article","venue":"ACS Omega","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Autophagy; Proinflammatory cytokine; PI3K/AKT/mTOR pathway; MAPK/ERK pathway; Protein kinase B; Cancer research; Cell biology; Biology; Viability assay; Cytokine; Protein kinase A; Kinase; Signal transduction; Cell; Inflammation; Immunology; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009937924,0.0001489093,0.0003745825,0.0001362548,0.0001354465,0.0001797035,0.0001020615,0.0002312104,0.0004186839],"category_scores_gemma":[0.00006066228,0.00008560709,0.0002779835,0.0001511282,0.00009136827,0.0001387992,0.00009852624,0.0002684132,0.0001487475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002839069,"about_ca_system_score_gemma":0.000212137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001121728,"about_ca_topic_score_gemma":0.001707556,"domain_scores_codex":[0.9998999,0.00001358813,0.00001197686,0.00002074483,0.00002393953,0.00002987622],"domain_scores_gemma":[0.9999796,0.000003866972,0.000003844574,0.00000265145,0.000006474125,0.000003659562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002705151,0.00005561065,0.000196806,0.00007190433,0.000009483967,0.00004533212,0.00002447568,0.00009609997,0.9964516,0.00005993,0.00008181677,0.00263641],"study_design_scores_gemma":[0.00002527531,0.0004193376,0.002298893,0.000004496177,0.00001888124,0.00008667181,0.00002229658,0.0009662362,0.9943497,0.00001910701,0.001785091,0.000004098355],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939491,0.002807773,0.001490637,0.0001098849,0.00004005635,0.00003737207,0.0002267752,0.00005150783,0.001287072],"genre_scores_gemma":[0.9947211,0.001379503,0.0017293,0.00007629189,0.000009911788,0.00007848257,0.0003751893,0.000006961082,0.001623318],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001121728,"threshold_uncertainty_score":0.002230346,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01148707979114794,"score_gpt":0.268532232946924,"score_spread":0.257045153155776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}