{"id":"W3035858046","doi":"10.1101/2020.06.16.146803","title":"Combining genome-wide studies of breast, prostate, ovarian and endometrial cancers maps cross-cancer susceptibility loci and identifies new genetic associations","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Calgary; University of Toronto; University Health Network; Foothills Medical Centre; Princess Margaret Cancer Centre; Sinai Health System; Lunenfeld-Tanenbaum Research Institute","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; National Cancer Institute; National Human Genome Research Institute; Instituto de Salud Carlos III; World Cancer Research Fund; Medical Research Council; Horizon 2020 Framework Programme; Hellenic Health Foundation; Cancer Council Victoria; Deutsche Krebshilfe; Genome Canada; Associazione Italiana per la Ricerca sul Cancro; Vetenskapsrådet; Canadian Institutes of Health Research; Cancerfonden; Swedish Cancer Foundation; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Cancer Research UK; Ovarian Cancer Research Fund; Prostate Cancer Foundation of Australia; Prostate Cancer Canada; Government of Canada; Centre International de Recherche sur le Cancer; National Institutes of Health; Rosetrees Trust; European Commission; Breast Cancer Research Foundation; Pancreatic Cancer UK; Movember Foundation; Prostate Cancer Foundation; Royal Marsden NHS Foundation Trust; National Cancer Research Institute; Deutsches Krebsforschungszentrum; National Health and Medical Research Council; Cancer Research Institute","keywords":"Biology; Genome-wide association study; Genetic association; Endometrial cancer; Breast cancer; Prostate cancer; Genetics; Gene; Cancer; Ovarian cancer; Single-nucleotide polymorphism; Pleiotropy; Oncology; Genotype; Medicine; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007355015,0.001397348,0.002101702,0.004120774,0.0006453503,0.003114946,0.00097482,0.0007812059,0.002909239],"category_scores_gemma":[0.008655103,0.0008028371,0.009265518,0.00531059,0.0005912627,0.0005846265,0.001665882,0.00117231,0.000339543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004699516,"about_ca_system_score_gemma":0.0008034559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004343759,"about_ca_topic_score_gemma":0.007056355,"domain_scores_codex":[0.9944983,0.002640088,0.0004134935,0.001436221,0.0006870504,0.0003248307],"domain_scores_gemma":[0.9918048,0.004626316,0.000958759,0.001924471,0.0003958115,0.0002897833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002092153,0.00007196237,0.7918777,0.001104934,0.1485862,0.001308321,0.0001808592,0.004014198,0.01713822,0.0006978519,0.001043993,0.03188352],"study_design_scores_gemma":[0.0004784255,0.0005620635,0.8244161,0.0004262719,0.1429395,0.002010646,0.0004086767,0.007244276,0.01075904,0.004831465,0.005814628,0.0001089446],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.893448,0.06525845,0.0325363,0.00111227,0.0002679164,0.00006404675,0.004542149,0.0005397478,0.002231119],"genre_scores_gemma":[0.9898244,0.00435683,0.003984545,0.0001633852,0.00009091423,0.0000212284,0.001124024,0.00006665155,0.0003681545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007355015,"threshold_uncertainty_score":0.03889751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02623812653162454,"score_gpt":0.2855927713473109,"score_spread":0.2593546448156863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}