{"id":"W3035858957","doi":"10.1101/2020.06.17.155788","title":"Genome-wide CRISPR knockout screen reveals membrane tethering complexes EARP and GARP important for Bovine Herpes Virus Type 1 replication","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; University of Toronto; University of Edinburgh","keywords":"CRISPR; Biology; Capsid; Genome; Gene; Viral replication; Endosome; Sindbis virus; Cell biology; Virus; Genetics; Virology; RNA; Cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002170441,0.0004867681,0.0004717422,0.000399779,0.000208135,0.000444452,0.0003407516,0.0004634091,0.001651367],"category_scores_gemma":[0.0001621562,0.0002596591,0.0003102911,0.0002245699,0.0002551161,0.0001276002,0.000295548,0.0004996975,0.0005674108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002836391,"about_ca_system_score_gemma":0.0001882648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007651778,"about_ca_topic_score_gemma":0.001356287,"domain_scores_codex":[0.999772,0.00003435235,0.00002835295,0.00005451962,0.00007368327,0.0000370554],"domain_scores_gemma":[0.9997929,0.00006796635,0.00005785677,0.00002180176,0.0000115967,0.00004802413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005031583,0.000008827364,0.0001640481,0.00002349361,0.000005997986,0.00009434983,0.000008451653,0.000113205,0.9988326,0.00006211528,0.00003762896,0.0005989327],"study_design_scores_gemma":[0.00002909799,0.0001884357,0.008227383,0.00001240686,0.00007301928,0.0008212946,0.00005266439,0.003919024,0.9817409,0.00008437885,0.004833747,0.00001766255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760439,0.0008885602,0.01695627,0.0001601511,0.0000492181,0.00006714529,0.003196763,0.0005766332,0.002061431],"genre_scores_gemma":[0.9881363,0.0004495984,0.006797056,0.00008306827,0.0000079928,0.00004013384,0.001899691,0.0001146239,0.002471634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001651367,"threshold_uncertainty_score":0.005524397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0318412807071026,"score_gpt":0.2784405651946519,"score_spread":0.2465992844875493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}