{"id":"W3035881142","doi":"10.1101/2020.06.18.159665","title":"Identification and Mechanistic Characterization of a Peptide Inhibitor of Glycogen Synthase Kinase (GSK3β) Derived from the Disrupted in Schizophrenia 1 (DISC1) Protein","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"University of California, Santa Barbara; National Institutes of Health; Saskatchewan Health Research Foundation","keywords":"Kinome; GSK-3; Peptide; Glycogen synthase; Biology; Biochemistry; Binding site; DISC1; Drug discovery; Kinase; Computational biology; Cell biology; Chemistry; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002275729,0.0002544909,0.0003007172,0.00007400845,0.00005607712,0.00004645806,0.0001937361,0.0002921141,0.000008191473],"category_scores_gemma":[0.0003177993,0.0002311158,0.00007285894,0.0001980812,0.0001133539,0.00001221744,0.0002577717,0.0001788928,0.000001835872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000308908,"about_ca_system_score_gemma":0.0001906479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006148701,"about_ca_topic_score_gemma":0.00001005611,"domain_scores_codex":[0.9983835,0.0001681317,0.0005775937,0.0005539287,0.0001779348,0.0001388719],"domain_scores_gemma":[0.9984983,0.0000184681,0.0006259538,0.0005585831,0.0002204629,0.00007821222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003872043,0.0000748689,0.001236072,0.0002344605,0.00006831229,0.000003052337,0.00001830814,0.00001034652,0.9978693,0.00008811925,0.000004059566,0.000005949904],"study_design_scores_gemma":[0.0005431338,0.00004879129,0.1418832,0.0003316618,0.00005392308,8.78531e-9,0.000005066858,0.0004990894,0.8563477,0.000005806954,0.0000869388,0.0001946616],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992344,0.000296598,0.005457183,0.0001744172,0.0002257366,0.0008643318,0.0006155568,0.00002188023,3.613981e-7],"genre_scores_gemma":[0.9989704,0.0001040289,0.0005001923,0.00003436811,0.000174798,0.000141262,0.00003146487,0.0000407269,0.00000270853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1415215,"threshold_uncertainty_score":0.9424629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008754443510638688,"score_gpt":0.2029735481960194,"score_spread":0.1942191046853807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}