{"id":"W3035881142","doi":"10.1101/2020.06.18.159665","title":"Identification and Mechanistic Characterization of a Peptide Inhibitor of Glycogen Synthase Kinase (GSK3β) Derived from the Disrupted in Schizophrenia 1 (DISC1) Protein","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"University of California, Santa Barbara; National Institutes of Health; Saskatchewan Health Research Foundation","keywords":"Kinome; GSK-3; Peptide; Glycogen synthase; Biology; Biochemistry; Binding site; DISC1; Drug discovery; Kinase; Computational biology; Cell biology; Chemistry; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000203594,0.0002449882,0.0002017792,0.0001089705,0.00009380402,0.0002376255,0.0001535813,0.0002383326,0.0006569067],"category_scores_gemma":[0.0001627127,0.00007794384,0.0001796944,0.00006480049,0.0001448877,0.0001281133,0.0001275948,0.0003248401,0.0002399306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001811668,"about_ca_system_score_gemma":0.0001444909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001366333,"about_ca_topic_score_gemma":0.0001285415,"domain_scores_codex":[0.9999421,0.00000831274,0.000006234873,0.00001324629,0.00001895667,0.0000111723],"domain_scores_gemma":[0.9999287,0.00001397012,0.00002079933,0.000005048249,0.000008448165,0.00002308218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000754225,0.00002479814,0.0001190718,0.00002339901,0.000003743519,0.00007319087,0.000007234668,0.0001254422,0.9983935,0.00008492022,0.0000285045,0.00104074],"study_design_scores_gemma":[0.00003736901,0.0005328984,0.002083952,0.000004607864,0.00001507665,0.0006220019,0.00001014662,0.001290239,0.9926592,0.00004804119,0.002691732,0.000004905082],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913927,0.001300026,0.005159469,0.00009267483,0.00003656707,0.00005724982,0.0004606288,0.00002878403,0.001471936],"genre_scores_gemma":[0.9869136,0.000740785,0.008636456,0.0001099846,0.00002166965,0.00004346075,0.001583083,0.00001719607,0.001933764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006569067,"threshold_uncertainty_score":0.002197564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008754443510638688,"score_gpt":0.2029735481960194,"score_spread":0.1942191046853807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}