{"id":"W3035910717","doi":"10.1002/pro.3901","title":"A mechanistic view of enzyme evolution","year":2020,"lang":"en","type":"review","venue":"Protein Science","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Mechanism (biology); Computational biology; Function (biology); Protein engineering; Directed Molecular Evolution; Directed evolution; Enzyme; Biology; Molecular evolution; Process (computing); Perspective (graphical); Computer science; Evolutionary biology; Genetics; Biochemistry; Phylogenetics; Artificial intelligence; Gene; Physics; Mutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003710179,0.0002525875,0.0006224895,0.00008729067,0.00008777028,0.00002627636,0.0008496086,0.0002016172,0.000008984915],"category_scores_gemma":[0.000395193,0.0002031881,0.0002037064,0.0006502304,0.000360672,0.000004874324,0.0003913697,0.0001536971,0.0000180184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005502991,"about_ca_system_score_gemma":0.001255233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008677418,"about_ca_topic_score_gemma":0.000002305248,"domain_scores_codex":[0.9983478,0.00006536052,0.0003761046,0.0006108519,0.0003344242,0.0002654298],"domain_scores_gemma":[0.9989138,0.000005926372,0.0003308877,0.0005124533,0.0001243736,0.0001125385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000005486617,0.00001303522,1.510993e-7,0.005322247,0.00002171035,0.000003463406,0.00000592169,7.299737e-7,0.04123023,0.007502005,0.00001627823,0.9458787],"study_design_scores_gemma":[0.00005989798,0.0002028975,3.33708e-7,0.001923003,0.00008636948,0.00003598544,0.000002225504,0.0000410811,0.007120598,0.001494615,0.9887477,0.0002852912],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000007846841,0.9729765,0.02539246,0.000008742338,0.00009880996,0.001039809,0.00004148087,0.00001141866,0.000422942],"genre_scores_gemma":[0.002231437,0.9928812,0.004391158,0.00001952139,0.0001505291,0.0001632271,0.0000352815,0.00002438017,0.000103302],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9887314,"threshold_uncertainty_score":0.8285769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0170187927920856,"score_gpt":0.2978283716899888,"score_spread":0.2808095788979031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}