{"id":"W3035910717","doi":"10.1002/pro.3901","title":"A mechanistic view of enzyme evolution","year":2020,"lang":"en","type":"review","venue":"Protein Science","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Mechanism (biology); Computational biology; Function (biology); Protein engineering; Directed Molecular Evolution; Directed evolution; Enzyme; Biology; Molecular evolution; Process (computing); Perspective (graphical); Computer science; Evolutionary biology; Genetics; Biochemistry; Phylogenetics; Artificial intelligence; Gene; Physics; Mutant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001249146,0.001476529,0.001310235,0.001634085,0.000552554,0.002198163,0.002053318,0.002545814,0.002087981],"category_scores_gemma":[0.0008004626,0.0005268431,0.0006841958,0.001583254,0.003615275,0.004787843,0.001358435,0.005028225,0.002010238],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002282779,"about_ca_system_score_gemma":0.001914536,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001195907,"about_ca_topic_score_gemma":0.000978468,"domain_scores_codex":[0.9995373,0.0001078119,0.00004501256,0.0001230619,0.0001316143,0.0000550467],"domain_scores_gemma":[0.9997368,0.0001375298,0.00002714058,0.00002027106,0.00005702806,0.00002111879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0001252744,0.0001020878,0.0003140405,0.01692542,0.0001570486,0.0005739918,0.0003698315,0.004297592,0.008408105,0.4387222,0.03502329,0.4949812],"study_design_scores_gemma":[0.00001019185,0.00007388827,0.0002201483,0.001418123,0.00003244299,0.0007077486,0.00006927663,0.0005036477,0.001240151,0.06666066,0.92904,0.00002359524],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002781798,0.986803,0.003269235,0.00296771,0.000813668,0.000008208372,0.00002265665,0.00002240051,0.005815001],"genre_scores_gemma":[0.005151706,0.989396,0.001491954,0.001405977,0.0004861249,0.00002208605,0.00003239546,0.000006110038,0.002007649],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002545814,"threshold_uncertainty_score":0.01656282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0170187927920856,"score_gpt":0.2978283716899888,"score_spread":0.2808095788979031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}