{"id":"W3035912196","doi":"10.1021/acs.analchem.0c02060","title":"Molecular Diagnosis of COVID-19: Challenges and Research Needs","year":2020,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"SARS-CoV-2 detection and testing","field":"Medicine","cited_by":392,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Innovates; Alberta Health; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Computational biology; Virology; RNA; Polymerase chain reaction; Virus; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002178544,0.00007409578,0.0001975072,0.000039377,0.00003030858,0.000007123436,0.00005738364,0.00009581225,0.000105675],"category_scores_gemma":[0.004304352,0.00006906468,0.00005554513,0.0003146884,0.0001841971,0.00001458209,0.00006995436,0.0002821758,0.00000777524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002751027,"about_ca_system_score_gemma":0.00009142565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000136155,"about_ca_topic_score_gemma":2.628038e-7,"domain_scores_codex":[0.9991739,0.00002297942,0.0001552989,0.0001946033,0.0002888277,0.0001643554],"domain_scores_gemma":[0.9990616,0.0003441088,0.00002371561,0.0001422322,0.000102799,0.0003255679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001480514,0.0001680165,0.009248278,0.002473999,0.0001643291,0.0003828679,0.0009602945,0.00000236114,0.9783615,0.000814768,0.001132734,0.006142767],"study_design_scores_gemma":[0.0005872363,0.0001104859,0.0002470604,0.00004934687,0.00006604862,0.00004389738,0.0009659934,0.001963375,0.9818591,0.0002208728,0.01380845,0.00007815189],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9592574,0.001938941,0.00004207083,0.01626229,0.000003663888,0.00005983502,0.000001602675,0.00004549079,0.02238871],"genre_scores_gemma":[0.9972497,0.0001914534,0.00007979175,0.002339107,0.00008630074,0.000008357624,0.000001457418,0.00001044294,0.0000333506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03799234,"threshold_uncertainty_score":0.5153022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1722813317201942,"score_gpt":0.4007258892780926,"score_spread":0.2284445575578984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}