{"id":"W3035950058","doi":"10.1172/jci.insight.136579","title":"Multiplexing DNA methylation markers to detect circulating cell-free DNA derived from human pancreatic β cells","year":2020,"lang":"en","type":"article","venue":"JCI Insight","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Novo Nordisk Fonden","keywords":"DNA methylation; Cell-free fetal DNA; Cell; DNA; Biology; Molecular biology; Type 2 diabetes; Methylation; Internal medicine; Diabetes mellitus; Immunology; Cancer research; Medicine; Endocrinology; Gene; Genetics; Gene expression; Pregnancy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007100293,0.0003694193,0.0001946666,0.000804348,0.0001320993,0.0003012306,0.0002429056,0.0005479149,0.001328205],"category_scores_gemma":[0.001254518,0.0002063243,0.0001390064,0.0003228256,0.0002325382,0.0002842579,0.0003811767,0.0006374692,0.000496052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001449847,"about_ca_system_score_gemma":0.000130804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001993028,"about_ca_topic_score_gemma":0.0005181706,"domain_scores_codex":[0.9995154,0.0001571637,0.00002572432,0.0001398065,0.0001100245,0.0000518515],"domain_scores_gemma":[0.9995066,0.0002817271,0.00007719566,0.00003711158,0.00004343436,0.00005380714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008623359,0.00002176909,0.003469906,0.00003623481,0.00001363209,0.0000376331,0.00006989713,0.0001058945,0.9845728,0.0001489133,0.0000716846,0.0113653],"study_design_scores_gemma":[0.00002025317,0.0005647414,0.01958811,0.00002237324,0.00004129705,0.001085028,0.0000666419,0.003293288,0.970438,0.0006799762,0.004175183,0.00002518785],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7262192,0.006142341,0.260503,0.0004312768,0.0001910076,0.0002426226,0.0009491199,0.0005713893,0.004750046],"genre_scores_gemma":[0.8192512,0.002434183,0.1727466,0.0004007038,0.0001077451,0.0003258443,0.000691283,0.00005126262,0.003991161],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001328205,"threshold_uncertainty_score":0.004443288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0324808286566222,"score_gpt":0.2509717583404091,"score_spread":0.2184909296837869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}