{"id":"W3035964002","doi":"10.1101/2020.06.20.20136184","title":"DNA hypohydroxymethylation in pediatric central nervous system tumors is associated with CTCF binding sites and reduced survival","year":2020,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Norris Cotton Cancer Center; National Institutes of Health; Dartmouth College","keywords":"CTCF; Epigenetics; Biology; Epigenome; CpG site; DNA binding site; Enhancer; DNA methylation; Cancer research; Glioma; Epigenomics; Neuropathology; microRNA; Transcription factor; Gene; Genetics; Pathology; Gene expression; Medicine; Disease; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001351704,0.0001289317,0.0001828614,0.0003356946,0.00009170381,0.000180262,0.0001013977,0.0001246881,0.001075331],"category_scores_gemma":[0.000338372,0.00008438727,0.0001177992,0.0003675993,0.0001443421,0.00006578662,0.0001424143,0.0001793217,0.0001051059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002124026,"about_ca_system_score_gemma":0.0001962272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003032655,"about_ca_topic_score_gemma":0.00343878,"domain_scores_codex":[0.9999278,0.000009656539,0.000004108031,0.00002627241,0.0000185803,0.00001365725],"domain_scores_gemma":[0.9997633,0.00004299271,0.0001302231,0.00001497068,0.0000203351,0.00002808592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006510745,0.00002358012,0.8518887,0.00006543333,0.00009092346,0.000295165,0.0001526009,0.001010679,0.1340249,0.0001343344,0.0003212645,0.01134123],"study_design_scores_gemma":[0.000003986105,0.00007300873,0.9784063,0.000004113343,0.00003402433,0.0007982278,0.0001088119,0.001190414,0.01874988,0.000103387,0.0005245491,0.000003269057],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981781,0.0002689968,0.0008450725,0.00001925054,0.000001727955,0.000002135779,0.0005196518,0.00001507322,0.0001499253],"genre_scores_gemma":[0.9985822,0.0001632864,0.00044933,0.000006810533,0.000001818667,0.000003696045,0.0005550734,0.000006884416,0.000230834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003032655,"threshold_uncertainty_score":0.006030023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0209972411021643,"score_gpt":0.2432237996828976,"score_spread":0.2222265585807333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}