{"id":"W3036073072","doi":"10.48336/wqzc-0m07","title":"Characterization of CG34126: the Drosophila melanogaster homologue of a novel Parkinson Disease gene","year":2020,"lang":"en","type":"dissertation","venue":"Memorial University Research Repository (Memorial University)","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Natural Sciences and Engineering Research Council of Canada; Memorial University of Newfoundland","keywords":"Drosophila melanogaster; Gene knockdown; Biology; PINK1; Parkin; RNA interference; Genetics; Parkinson's disease; Dopaminergic; Gene; Neurodegeneration; Ectopic expression; Phenotype; Transgene; Aromatic L-amino acid decarboxylase; Model organism; Gene silencing; Cell biology; Dopamine; Neuroscience; Disease; RNA; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000809018,0.0005459436,0.0001944841,0.0004014621,0.0002083413,0.0001854572,0.000361904,0.0004518965,0.001377861],"category_scores_gemma":[0.0001075493,0.0001388503,0.0003568516,0.0002891688,0.0002043636,0.0001177253,0.0002067483,0.0005771627,0.001056345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000430434,"about_ca_system_score_gemma":0.0002813305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002115745,"about_ca_topic_score_gemma":0.003758471,"domain_scores_codex":[0.999917,0.000008627006,0.00001175115,0.00002560579,0.00002503156,0.00001193862],"domain_scores_gemma":[0.9999179,0.00001218565,0.00002279614,0.000008966098,0.00001099174,0.00002726081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002271433,0.000008574189,0.0001134608,0.00002451177,0.000002411777,0.0001145976,0.000006790302,0.0000587601,0.9986713,0.00006836335,0.0000764643,0.0008320723],"study_design_scores_gemma":[0.00004896395,0.0002920175,0.02178651,0.00003000537,0.00004679825,0.002073389,0.00005628111,0.002018608,0.9421253,0.0000944292,0.03139831,0.00002932487],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9602126,0.002650933,0.01305477,0.0004029814,0.0001191853,0.0003671622,0.01598694,0.0003330566,0.006872334],"genre_scores_gemma":[0.9280264,0.001944528,0.01862966,0.0003646436,0.00002910677,0.00020525,0.03635293,0.0002027106,0.01424477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002115745,"threshold_uncertainty_score":0.004609346,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03126771881903797,"score_gpt":0.2621933080104863,"score_spread":0.2309255891914483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}