{"id":"W3036088510","doi":"10.1016/j.xcrm.2020.100038","title":"Pattern of Relapse and Treatment Response in WNT-Activated Medulloblastoma","year":2020,"lang":"en","type":"article","venue":"Cell Reports Medicine","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Hamilton General Hospital; University of British Columbia; Hospital for Sick Children; McMaster University; SickKids Foundation; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; Stand Up To Cancer; National Cancer Institute; University of Toronto; National Institutes of Health; Ontario Ministry of Research, Innovation and Science; Royal Children's Hospital Foundation; Children's Hospital Foundation; Children’s Hospital of Wisconsin Research Institute; C.R. Younger Foundation; Brain Tumour Foundation of Canada; Murdoch Children's Research Institute; Univerzita Karlova v Praze; CURE Childhood Cancer; Canadian Institutes of Health Research; Associazione Italiana per la Ricerca sul Cancro; Pediatric Brain Tumor Foundation; Government of Ontario; St. Baldrick's Foundation; Princess Margaret Cancer Foundation; Grantová Agentura, Univerzita Karlova; Hospital for Sick Children; American Brain Tumor Association","keywords":"Cyclophosphamide; Medulloblastoma; Oncology; Chemotherapy; Medicine; Internal medicine; Cohort; Wnt signaling pathway; Regimen; Radiation therapy; Pathology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004754974,0.0000831405,0.000281631,0.0005823558,0.0001528552,0.0003299076,0.0001972441,0.0002090756,0.0009007282],"category_scores_gemma":[0.001819614,0.00007162336,0.0001999669,0.0003714469,0.0002248331,0.0002344564,0.0002844919,0.0002933667,0.0001849347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005258259,"about_ca_system_score_gemma":0.0002311037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003347735,"about_ca_topic_score_gemma":0.004919482,"domain_scores_codex":[0.9995764,0.000103961,0.0000442039,0.00008770162,0.00008592308,0.000101795],"domain_scores_gemma":[0.9991707,0.0001622522,0.0003968871,0.00006293569,0.00007505404,0.0001322843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001221199,0.00005455554,0.9745336,0.00001650156,0.00006633703,0.0003263897,0.0002612559,0.0002522791,0.0039538,0.00007154517,0.0003108257,0.0189317],"study_design_scores_gemma":[0.000006709206,0.0002219439,0.9978579,0.000004695015,0.00001659153,0.0006071714,0.000158692,0.0002529883,0.0005228911,0.00006477882,0.000281341,0.000004339476],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986925,0.0003408871,0.00009110801,0.00006859592,0.000002614228,0.000005746008,0.0001701774,0.00001115401,0.0006173445],"genre_scores_gemma":[0.9995487,0.00006498885,0.00003541749,0.00002198413,0.000002080811,0.000003199656,0.0001632866,0.00000389861,0.000156447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003347735,"threshold_uncertainty_score":0.006656468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02178271997972442,"score_gpt":0.2622657163412733,"score_spread":0.2404829963615489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}