{"id":"W3036088510","doi":"10.1016/j.xcrm.2020.100038","title":"Pattern of Relapse and Treatment Response in WNT-Activated Medulloblastoma","year":2020,"lang":"en","type":"article","venue":"Cell Reports Medicine","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Hamilton General Hospital; University of British Columbia; Hospital for Sick Children; McMaster University; SickKids Foundation; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; Stand Up To Cancer; National Cancer Institute; University of Toronto; National Institutes of Health; Ontario Ministry of Research, Innovation and Science; Royal Children's Hospital Foundation; Children's Hospital Foundation; Children’s Hospital of Wisconsin Research Institute; C.R. Younger Foundation; Brain Tumour Foundation of Canada; Murdoch Children's Research Institute; Univerzita Karlova v Praze; CURE Childhood Cancer; Canadian Institutes of Health Research; Associazione Italiana per la Ricerca sul Cancro; Pediatric Brain Tumor Foundation; Government of Ontario; St. Baldrick's Foundation; Princess Margaret Cancer Foundation; Grantová Agentura, Univerzita Karlova; Hospital for Sick Children; American Brain Tumor Association","keywords":"Cyclophosphamide; Medulloblastoma; Oncology; Chemotherapy; Medicine; Internal medicine; Cohort; Wnt signaling pathway; Regimen; Radiation therapy; Pathology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002281308,0.0002052569,0.0006325886,0.0001542372,0.00001936622,0.000002507473,0.00002406009,0.00007772448,0.0002031297],"category_scores_gemma":[0.0003182028,0.0001364407,0.0000561987,0.0002716591,0.0001191145,0.00002911396,0.00002547042,0.00009185054,0.000003481116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001038819,"about_ca_system_score_gemma":0.00008791217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003821917,"about_ca_topic_score_gemma":0.00001599662,"domain_scores_codex":[0.9984859,0.00006640951,0.0006016848,0.0003828929,0.0002724528,0.0001906879],"domain_scores_gemma":[0.9989017,0.0001785546,0.0002457058,0.0002870242,0.00005815637,0.0003288443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003374778,0.001088104,0.3596911,0.0001722518,0.0001306675,0.02675813,0.005197385,0.000008396872,0.5858853,0.000002018374,0.001166806,0.01652498],"study_design_scores_gemma":[0.01266449,0.01245008,0.4781278,0.0008062411,0.0004226216,0.001247745,0.001469528,0.0001132958,0.4825701,0.00001767683,0.009884119,0.0002262189],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988044,0.001227065,0.000006745338,0.009216783,0.00008842692,0.0005219192,0.000002033315,0.00003370495,0.0008593561],"genre_scores_gemma":[0.9988293,0.0003321659,0.00005060811,0.000493555,0.0000711952,0.00003771099,0.00002272728,0.00002407879,0.0001386614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1184367,"threshold_uncertainty_score":0.5563892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02178271997972442,"score_gpt":0.2622657163412733,"score_spread":0.2404829963615489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}