{"id":"W3036100757","doi":"10.1016/j.jhep.2020.06.011","title":"Similar risk of hepatocellular carcinoma during long-term entecavir or tenofovir therapy in Caucasian patients with chronic hepatitis B","year":2020,"lang":"en","type":"article","venue":"Journal of Hepatology","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":88,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network","funders":"Merck Sharp and Dohme; Gilead Sciences; Roche; Novartis; AbbVie; Merck; GlaxoSmithKline; Janssen Pharmaceuticals; Bayer; Bristol-Myers Squibb","keywords":"Medicine; Hepatocellular carcinoma; Entecavir; Cirrhosis; Internal medicine; Gastroenterology; Hazard ratio; Incidence (geometry); HBsAg; Hepatitis B; Cumulative incidence; Proportional hazards model; Liver transplantation; Cohort; Hepatitis B virus; Transplantation; Immunology; Lamivudine; Confidence interval; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004640443,0.0001789909,0.000368893,0.0004257693,0.0004943748,0.0006337962,0.0001244708,0.0004153059,0.001949372],"category_scores_gemma":[0.001433963,0.0001808846,0.0007712021,0.0006186191,0.0001924068,0.0004264952,0.0002110027,0.0005863936,0.0001760471],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002310024,"about_ca_system_score_gemma":0.0003316613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004892455,"about_ca_topic_score_gemma":0.005327082,"domain_scores_codex":[0.9996885,0.0001105211,0.00003444257,0.00005845217,0.00003490977,0.00007314532],"domain_scores_gemma":[0.9991874,0.0001777005,0.0002495898,0.00009410158,0.0000757571,0.000215431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001889578,0.00006966667,0.9942244,0.0000175034,0.0001787459,0.0002579908,0.000116527,0.00002220262,0.00116426,0.00003981502,0.00006499793,0.001954415],"study_design_scores_gemma":[0.00002003537,0.0002544745,0.9987915,0.000003830705,0.00007937129,0.0003213093,0.0001892128,0.00005544535,0.00007543832,0.0000182035,0.000187006,0.000004261905],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985066,0.0004589478,0.00004015093,0.00003345458,0.00001124322,0.000004061989,0.00009420764,0.000001728397,0.0008496662],"genre_scores_gemma":[0.9994258,0.0001545852,0.00002465092,0.00002711511,0.00001654473,0.000002530439,0.0001203064,0.000001465822,0.0002269091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004892455,"threshold_uncertainty_score":0.009727955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01909323869572797,"score_gpt":0.250120275602785,"score_spread":0.2310270369070571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}