{"id":"W3036153593","doi":"10.1200/jco.19.03114","title":"Event-Free Survival, a Prostate-Specific Antigen–Based Composite End Point, Is Not a Surrogate for Overall Survival in Men With Localized Prostate Cancer Treated With Radiation","year":2020,"lang":"en","type":"review","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Diagnosis and Treatment","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Cancer Institute; Medical Research Council","keywords":"Medicine; Prostate cancer; Surrogate endpoint; Proportional hazards model; Oncology; Hazard ratio; Clinical endpoint; Internal medicine; Prostate-specific antigen; Clinical trial; Radiation therapy; Survival analysis; Cancer; Urology; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.06146532,0.0007777054,0.002882442,0.001384994,0.0002228422,0.001746064,0.0008035483,0.0005704127,0.0006687817],"category_scores_gemma":[0.0501155,0.0004753192,0.01163932,0.001658718,0.0007458726,0.000912136,0.0006783637,0.001320535,0.00007164691],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000590162,"about_ca_system_score_gemma":0.000865019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001188526,"about_ca_topic_score_gemma":0.001880014,"domain_scores_codex":[0.9627138,0.03076936,0.002429886,0.00178271,0.0020023,0.0003019237],"domain_scores_gemma":[0.9147937,0.06990929,0.008493214,0.005455496,0.001065991,0.0002823016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"observational","study_design_scores_codex":[0.02518257,0.0002485771,0.3577246,0.009981243,0.5016143,0.0001795142,0.000146003,0.01825994,0.001434687,0.001505296,0.001066947,0.08265629],"study_design_scores_gemma":[0.005249728,0.007861315,0.4186255,0.002746416,0.5080931,0.0006497397,0.0001771097,0.03458453,0.003539262,0.00813378,0.01019958,0.000139966],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.6269542,0.3395117,0.02495072,0.001807912,0.0003327163,0.0004047541,0.002513648,0.0001228034,0.003401414],"genre_scores_gemma":[0.9835934,0.01303313,0.001815632,0.0004330085,0.0001463036,0.0001391705,0.0005758635,0.00001662242,0.0002467973],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.06146532,"threshold_uncertainty_score":0.3250636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1259666433807745,"score_gpt":0.4443648717416813,"score_spread":0.3183982283609068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}