{"id":"W3036164086","doi":"10.7554/elife.53889","title":"The E2 Marie Kondo and the CTLH E3 ligase clear deposited RNA binding proteins during the maternal-to-zygotic transition","year":2020,"lang":"en","type":"article","venue":"eLife","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; University of Colorado","keywords":"Ubiquitin ligase; Maternal to zygotic transition; Biology; Cell biology; Transcriptome; Genetics; RNA; RNA-binding protein; Ubiquitin; Gene; Zygote; Gene expression; Embryogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003155496,0.0001040355,0.00008908148,0.000013776,0.0005713055,0.0001672744,0.0002421498,0.00004818294,0.000004418263],"category_scores_gemma":[0.0001944982,0.00005198722,0.00005935621,0.0001022964,0.0001108173,0.000004566428,0.000130151,0.0001616573,0.00001989967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008536186,"about_ca_system_score_gemma":0.00002453048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009132124,"about_ca_topic_score_gemma":0.00003264199,"domain_scores_codex":[0.9990455,0.0001353871,0.0001442369,0.0002025633,0.0002070028,0.0002653344],"domain_scores_gemma":[0.9995365,0.00004125084,0.00003757203,0.0002194823,0.00003761456,0.0001275894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007628928,0.000005569906,0.0003526618,0.00002387727,0.0000469876,0.00001101895,0.0002951038,0.00007084288,0.9973006,0.00004501813,0.0002157921,0.0008696017],"study_design_scores_gemma":[0.00116066,0.0001940099,0.004214816,0.00003004621,0.00001810818,0.00002161462,0.0003305263,0.001793825,0.9892548,0.000007574663,0.00285616,0.0001178678],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868878,0.0005179976,0.0004063855,0.01152222,0.00002698458,0.0005226672,0.000006868935,0.00001327916,0.00009577813],"genre_scores_gemma":[0.9974134,0.0004448582,0.00005555754,0.001344479,0.0002492313,0.00004800339,0.000006249077,0.00001853507,0.0004197073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01052556,"threshold_uncertainty_score":0.4394077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006750004198923635,"score_gpt":0.221634500118684,"score_spread":0.2148844959197604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}