{"id":"W3036170109","doi":"10.1016/j.cub.2020.05.070","title":"Metabolic Reconfiguration in C. elegans Suggests a Pathway for Widespread Sterol Auxotrophy in the Animal Kingdom","year":2020,"lang":"en","type":"article","venue":"Current Biology","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Planning and Budgeting Committee of the Council for Higher Education of Israel; Canadian Institutes of Health Research; National Institutes of Health; Israel Science Foundation","keywords":"Biology; Auxotrophy; Sterol; Microbiology; Genetics; Biochemistry; Cholesterol; Gene; Mutant","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001137524,0.0003770169,0.0002716263,0.0005181454,0.0003817553,0.0004416119,0.0002539452,0.0004869432,0.001062908],"category_scores_gemma":[0.0001697511,0.0002582587,0.0002805013,0.000174685,0.0004448475,0.0005759175,0.0003934135,0.000480457,0.0001889496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003790854,"about_ca_system_score_gemma":0.0003949416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001901689,"about_ca_topic_score_gemma":0.003760149,"domain_scores_codex":[0.9999255,0.000005646338,0.00000604682,0.00002948001,0.00001665468,0.00001658847],"domain_scores_gemma":[0.9998579,0.00001720651,0.00003270935,0.00002504108,0.0000232633,0.00004395359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001646227,0.00000789002,0.0007063362,0.00002838464,0.000006081842,0.0001371845,0.00001318299,0.000181873,0.9962387,0.0004894265,0.00004300308,0.001983307],"study_design_scores_gemma":[0.00008115284,0.0006783436,0.1199076,0.00005286884,0.00009632581,0.002150242,0.000259349,0.01020748,0.8549147,0.005304505,0.006256475,0.00009108723],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896993,0.0009761605,0.006203218,0.0003321452,0.00003483397,0.00001524458,0.0004622457,0.0002491009,0.002027723],"genre_scores_gemma":[0.9948708,0.0005465063,0.003428548,0.00007095341,0.000005235407,0.00001300391,0.0002217492,0.00002280536,0.0008204615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001901689,"threshold_uncertainty_score":0.003781259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04818370826326138,"score_gpt":0.2992643845373533,"score_spread":0.2510806762740919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}