{"id":"W3036174462","doi":"10.1111/dom.14118","title":"γ‐aminobutyric acid stimulates β‐cell proliferation through the <scp>mTORC1</scp> / <scp>p70S6K</scp> pathway, an effect amplified by <scp>Ly49</scp> , a novel γ‐aminobutyric acid type A receptor positive allosteric modulator","year":2020,"lang":"en","type":"article","venue":"Diabetes Obesity and Metabolism","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University Health Network; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Cell growth; mTORC1; Receptor; Cell biology; PI3K/AKT/mTOR pathway; Aminobutyric acid; Cell; Chemistry; Endocrinology; Internal medicine; Signal transduction; Biology; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009748757,0.0003067103,0.0002235549,0.0001497307,0.0001029358,0.0002345959,0.0001190748,0.0001832189,0.002227985],"category_scores_gemma":[0.00006357194,0.0001241406,0.0002536379,0.0001049448,0.0001615939,0.0001275325,0.0001308476,0.0004831842,0.0005067555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001583773,"about_ca_system_score_gemma":0.0001681508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002937792,"about_ca_topic_score_gemma":0.0006143803,"domain_scores_codex":[0.9999326,0.00001211971,0.000007752666,0.0000126054,0.00001743614,0.00001751748],"domain_scores_gemma":[0.9999546,0.000007647393,0.00001536525,0.000004883304,0.000004452121,0.00001309978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001893531,0.00001975883,0.00009329217,0.00003648565,0.000006453337,0.00002002334,0.000002556123,0.00002843482,0.9986975,0.000025161,0.00003952745,0.0008415298],"study_design_scores_gemma":[0.00004438548,0.0004586832,0.003800602,0.000008183098,0.00002032429,0.0001294053,0.00001763029,0.000531134,0.9936215,0.00002421912,0.001340884,0.000002842875],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930419,0.002758241,0.001449117,0.0001872763,0.00005114364,0.00002505325,0.0003487482,0.0001112459,0.002027371],"genre_scores_gemma":[0.9948022,0.002037565,0.001161217,0.000086793,0.00002028416,0.00004208049,0.0002704023,0.00002356363,0.001555918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002227985,"threshold_uncertainty_score":0.007453382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01490930577351314,"score_gpt":0.225357025200545,"score_spread":0.2104477194270319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}