{"id":"W3036185872","doi":"10.3390/cancers12061664","title":"Roles of Histone Deacetylases and Inhibitors in Anticancer Therapy","year":2020,"lang":"en","type":"review","venue":"Cancers","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":144,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Histone Acetyltransferases; Histone; Acetylation; Chromatin; Epigenetics; Cancer epigenetics; Biology; Histone deacetylase; Histone-modifying enzymes; Cell biology; Chromatin remodeling; Cancer research; Histone methyltransferase; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001498331,0.0003318136,0.00102539,0.0001600849,0.00002979,0.00001046633,0.0002420809,0.0003283547,0.00002323125],"category_scores_gemma":[0.0001064685,0.0003021865,0.0002251627,0.0003014307,0.0003493801,0.000003276243,0.0001279447,0.0002854178,0.000005261105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000519869,"about_ca_system_score_gemma":0.001924164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001712632,"about_ca_topic_score_gemma":0.0002381373,"domain_scores_codex":[0.9983055,0.0001430101,0.0004784561,0.0005723222,0.0002125505,0.0002881912],"domain_scores_gemma":[0.9992336,0.00003392122,0.0002137493,0.0003335009,0.00005289683,0.0001323008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000563742,0.00001552872,0.00001242833,0.002921297,0.0001057024,0.00001860844,0.00009040579,0.000006750082,0.004049303,0.000007539782,0.004834316,0.9878817],"study_design_scores_gemma":[0.0003579538,0.0001868866,0.000001611217,0.001840821,0.00003074905,0.00001089873,0.00002905346,0.000003042956,0.01103706,0.000001548474,0.9862263,0.0002740824],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006091798,0.9927855,0.000003631529,0.00002626627,0.0001398654,0.0005121697,0.0001014411,0.000007670319,0.0003316949],"genre_scores_gemma":[0.001735209,0.9973745,0.00005172111,0.00003775472,0.0003004522,0.0001214636,0.00008373043,0.00006831965,0.0002268752],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9876077,"threshold_uncertainty_score":0.999943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03067658152703958,"score_gpt":0.3753251756396718,"score_spread":0.3446485941126323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}