{"id":"W3036185872","doi":"10.3390/cancers12061664","title":"Roles of Histone Deacetylases and Inhibitors in Anticancer Therapy","year":2020,"lang":"en","type":"review","venue":"Cancers","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":144,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Histone Acetyltransferases; Histone; Acetylation; Chromatin; Epigenetics; Cancer epigenetics; Biology; Histone deacetylase; Histone-modifying enzymes; Cell biology; Chromatin remodeling; Cancer research; Histone methyltransferase; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005952853,0.0009134936,0.001282809,0.001957921,0.0002702322,0.0009221691,0.001000108,0.001038506,0.004386518],"category_scores_gemma":[0.000644561,0.0002668028,0.0005907774,0.001727302,0.0005159899,0.001328819,0.0006655402,0.002697305,0.00250003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007949701,"about_ca_system_score_gemma":0.0007204761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006485805,"about_ca_topic_score_gemma":0.001434095,"domain_scores_codex":[0.9997445,0.00004931378,0.00002990293,0.00004228003,0.0001058972,0.00002801285],"domain_scores_gemma":[0.9997923,0.00009473789,0.00002510582,0.000009037447,0.00005476215,0.00002406803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001182535,0.0001321442,0.0001217206,0.01156297,0.000110594,0.0002931663,0.0000607221,0.0004976938,0.002663272,0.007065642,0.05290867,0.9244652],"study_design_scores_gemma":[0.00002231285,0.00008815616,0.0003515545,0.0013914,0.00006211001,0.0007978823,0.00002103259,0.00007684037,0.0004340871,0.00167294,0.9950706,0.00001109746],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009419346,0.998082,0.000128145,0.0002488787,0.0003143902,0.000005732614,0.0000152421,0.000008433318,0.001102924],"genre_scores_gemma":[0.0007008121,0.9975351,0.000202407,0.0002338671,0.0002502131,0.000009825487,0.00003199498,0.000002236981,0.001033586],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004386518,"threshold_uncertainty_score":0.01467437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03067658152703958,"score_gpt":0.3753251756396718,"score_spread":0.3446485941126323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}