{"id":"W3036229222","doi":"10.1038/s41929-020-0469-2","title":"Cycling back to biocatalysis","year":2020,"lang":"en","type":"article","venue":"Nature Catalysis","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biocatalysis; Peptide; Chemistry; Enzyme; Catalysis; Biochemistry; Combinatorial chemistry; Biochemical engineering; Engineering; Reaction mechanism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003221542,0.0001362401,0.0001472622,0.00002950431,0.00004351236,0.000032313,0.0002223666,0.0003021936,0.00006900375],"category_scores_gemma":[0.000172413,0.0001175035,0.0001322587,0.0004104231,0.00002047951,0.000003845217,0.0001251888,0.0001661256,0.0001417022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006951991,"about_ca_system_score_gemma":0.00001243425,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003910689,"about_ca_topic_score_gemma":0.000002890652,"domain_scores_codex":[0.9991431,0.00001347658,0.0001500941,0.0004137242,0.000121352,0.0001583019],"domain_scores_gemma":[0.9994492,0.000003874253,0.00004356823,0.0002327782,0.0000743796,0.00019621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004377969,0.000006080229,0.0008272503,0.0000115914,0.000057118,8.400829e-7,0.00003608618,0.00001514841,0.9942643,0.000009910042,0.002706579,0.002021311],"study_design_scores_gemma":[0.0001155142,0.00004926329,0.001039492,0.000003089002,0.00004150954,0.000002032535,0.00001536317,0.00007201758,0.9523001,0.000006800234,0.04617177,0.0001830965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936119,0.0003724305,0.0009657818,0.004420329,0.00007606489,0.000089417,0.00004386791,0.00001944149,0.0004007902],"genre_scores_gemma":[0.9900289,0.00002105375,0.0009284336,0.006333433,0.0005316923,0.000005072534,0.001933226,0.00001510085,0.0002030579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04346519,"threshold_uncertainty_score":0.4791653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006529395296051258,"score_gpt":0.2318822970019422,"score_spread":0.2253529017058909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}