{"id":"W3036240123","doi":"10.1182/bloodadvances.2020001736","title":"Diagnostic assay to assist clinical decisions for unclassified severe combined immune deficiency","year":2020,"lang":"en","type":"article","venue":"Blood Advances","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Organoid; Immune system; Phenotype; CD34; Immunology; Peripheral blood; Medicine; Cellular differentiation; Biology; Bioinformatics; Stem cell; Neuroscience; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001396202,0.001178546,0.0006031162,0.003376497,0.0004292952,0.001320724,0.0009008054,0.001449358,0.008552728],"category_scores_gemma":[0.004459478,0.0002473581,0.0005327676,0.0007645499,0.0004616611,0.0005356488,0.0004740954,0.00134555,0.005061182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005689109,"about_ca_system_score_gemma":0.0004942081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001169174,"about_ca_topic_score_gemma":0.001057265,"domain_scores_codex":[0.9989511,0.0003206107,0.0001689688,0.0001547052,0.0002905202,0.000114005],"domain_scores_gemma":[0.9977587,0.0008334073,0.0002463617,0.0001453137,0.0007578067,0.0002583597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002023577,0.0005942045,0.5054042,0.0007994893,0.0001557277,0.02103244,0.0003629024,0.001728927,0.07205137,0.005235044,0.07797417,0.312638],"study_design_scores_gemma":[0.0003639068,0.002517017,0.3010654,0.003976911,0.0008280234,0.1600914,0.002061686,0.03845695,0.1789915,0.01724263,0.2941139,0.0002906226],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.5291925,0.08737458,0.1630787,0.02718549,0.005617449,0.001618912,0.01297882,0.006898239,0.1660552],"genre_scores_gemma":[0.8897258,0.007732124,0.07820123,0.005011984,0.001264658,0.0004066728,0.004338636,0.0001855676,0.01313331],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.008552728,"threshold_uncertainty_score":0.02861172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03508239359368968,"score_gpt":0.3026999698242738,"score_spread":0.2676175762305841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}