{"id":"W3036240123","doi":"10.1182/bloodadvances.2020001736","title":"Diagnostic assay to assist clinical decisions for unclassified severe combined immune deficiency","year":2020,"lang":"en","type":"article","venue":"Blood Advances","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Organoid; Immune system; Phenotype; CD34; Immunology; Peripheral blood; Medicine; Cellular differentiation; Biology; Bioinformatics; Stem cell; Neuroscience; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005829507,0.0003048317,0.0006150067,0.00007138291,0.0005950861,0.00003766667,0.0006979418,0.0002380338,0.0001866642],"category_scores_gemma":[0.008681905,0.0002648936,0.0003365377,0.0004163974,0.0002700963,0.0001825285,0.0001875979,0.0003668344,0.0006806004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001216734,"about_ca_system_score_gemma":0.0001287402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008599195,"about_ca_topic_score_gemma":0.000004942462,"domain_scores_codex":[0.9975232,0.0002473875,0.0008825116,0.0006504905,0.000069218,0.0006272336],"domain_scores_gemma":[0.9951037,0.004083921,0.0002202162,0.00041313,0.0001369435,0.0000421353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004317758,0.008105918,0.03715717,0.0002644655,0.001076241,0.00004230593,0.003140012,0.00141,0.2376508,0.02890018,0.01001374,0.6679214],"study_design_scores_gemma":[0.01567284,0.004903862,0.08708588,0.000281287,0.0005967463,0.0000490045,0.002775263,0.0000587149,0.02400107,0.002821062,0.8601768,0.001577467],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7286221,0.2073002,0.03388995,0.01212446,0.006381291,0.003408604,0.0004725049,0.0007434681,0.007057365],"genre_scores_gemma":[0.9960842,0.0005131644,0.0006931446,0.001599109,0.0000209833,0.0001685291,0.0001675746,0.00003198319,0.0007212916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.850163,"threshold_uncertainty_score":0.9999803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03508239359368968,"score_gpt":0.3026999698242738,"score_spread":0.2676175762305841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}